Warning: no access to tty (Bad file descriptor). Thus no job control in this shell. lmbwide.login complete +------------------------------------------------ LMB crystallography software CCP4 release 6.5 installed 12/01/2015 updated Feb 201 Phil Evans If you really want to use the older (6.4.0) version, edit your .login to "source /public/xtal/ccp4/xtal-6.4.0.login" and login again ------------------------------------------------------------------------------ phenix release 1.10 installed 9.9.15 Phil Evans Type "phenix &" to get GUI ------------------------------------------------------------------------------ sharp server is on hal:8082, Sharp version 2.8.2 Phil Evans/Roger Williams ------------------------------------------------------------------------------ coot now points to the very latest. Stable coot is available with old-coot ------------------------------------------------------------------------------ imosflm (1.0.7) and ipmosflm (7.0.9) May 2012 ------------------------------------------------------------------------------ qtmg or ccp4mg run the CCP4 molecular graphics program ------------------------------------------------------------------------------ MAIN 2014 Jan Löwe 10/14 ------------------------------------------------------------------------------ ************************************************** MRC image processing programs have moved. You are using image2010 by default. If you wish to use the frozen image2000 you need to : source /public/EM/image2000/com/image.login and source /public/EM/image2000/com/image.cshrc Jude Short (F46 x2039 jms@mrc-lmb.cam.ac.uk) 09.03.2011 ************************************************** === RELION MPI setup === + Number of MPI processes = 4 + Number of threads per MPI process = 8 + Total number of threads therefore = 32 + Master (0) runs on host = fmb341.lmb.internal + Slave 2 runs on host = fmb341.lmb.internal ================= + Slave 1 runs on host = fmb178.lmb.internal + Slave 3 runs on host = fmb178.lmb.internal Running in double precision. Estimating initial noise spectra 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 1/ 20 sec ..~~(,_,"> 1/ 15 sec ...~~(,_,"> 1/ 12 sec ....~~(,_,"> 1/ 10 sec .....~~(,_,"> 2/ 17 sec ......~~(,_,"> 2/ 15 sec .......~~(,_,"> 2/ 13 sec ........~~(,_,"> 2/ 12 sec .........~~(,_,"> 2/ 11 sec ..........~~(,_,"> 2/ 10 sec ...........~~(,_,"> 3/ 14 sec ............~~(,_,"> 3/ 13 sec .............~~(,_,"> 3/ 12 sec ..............~~(,_,"> 3/ 11 sec ...............~~(,_,"> 3/ 10 sec ................~~(,_,"> 4/ 13 sec .................~~(,_,"> 4/ 12 sec ..................~~(,_,"> 4/ 12 sec ...................~~(,_,"> 4/ 11 sec ....................~~(,_,"> 4/ 11 sec .....................~~(,_,"> 4/ 10 sec ......................~~(,_,"> 5/ 12 sec .......................~~(,_,"> 5/ 12 sec ........................~~(,_,"> 5/ 11 sec .........................~~(,_,"> 5/ 11 sec ..........................~~(,_,"> 6/ 13 sec ...........................~~(,_,"> 6/ 12 sec ............................~~(,_,"> 6/ 12 sec .............................~~(,_,"> 6/ 11 sec ..............................~~(,_,"> 6/ 11 sec ...............................~~(,_,"> 7/ 12 sec ................................~~(,_,"> 7/ 12 sec .................................~~(,_,"> 7/ 12 sec ..................................~~(,_,"> 8/ 13 sec ...................................~~(,_,"> 8/ 13 sec ....................................~~(,_,"> 8/ 12 sec .....................................~~(,_,"> 8/ 12 sec ......................................~~(,_,"> 9/ 13 sec .......................................~~(,_,"> 9/ 13 sec ........................................~~(,_,"> 9/ 13 sec .........................................~~(,_,"> 9/ 12 sec ..........................................~~(,_,"> 9/ 12 sec ...........................................~~(,_,"> 9/ 12 sec ............................................~~(,_,"> 10/ 13 sec .............................................~~(,_,"> 10/ 13 sec ..............................................~~(,_,"> 10/ 12 sec ...............................................~~(,_,"> 10/ 12 sec ................................................~~(,_,"> 10/ 12 sec .................................................~~(,_,"> 11/ 13 sec ..................................................~~(,_,"> 11/ 12 sec ...................................................~~(,_,"> 11/ 12 sec ...................................................~~(,_,"> 11/ 12 sec ....................................................~~(,_,"> 11/ 12 sec .....................................................~~(,_,"> 12/ 13 sec ......................................................~~(,_,"> 12/ 12 sec .......................................................~~(,_,"> 12/ 12 sec ........................................................~~(,_,"> 12/ 12 sec .........................................................~~(,_,"> 12/ 12 sec ..........................................................~~(,_,"> 12/ 12 sec ...........................................................~~(,_,"> 12/ 12 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 1/ 50 sec .~~(,_,"> 1/ 40 sec .~~(,_,"> 1/ 33 sec .~~(,_,"> 1/ 28 sec ..~~(,_,"> 1/ 25 sec ..~~(,_,"> 1/ 22 sec ..~~(,_,"> 1/ 20 sec ...~~(,_,"> 1/ 18 sec ...~~(,_,"> 1/ 16 sec ...~~(,_,"> 1/ 15 sec ...~~(,_,"> 1/ 14 sec ....~~(,_,"> 1/ 13 sec ....~~(,_,"> 1/ 12 sec ....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 10 sec .....~~(,_,"> 1/ 10 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 8 sec ......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 2/ 8 sec .............~~(,_,"> 2/ 8 sec .............~~(,_,"> 2/ 8 sec ..............~~(,_,"> 2/ 8 sec ..............~~(,_,"> 2/ 8 sec ..............~~(,_,"> 2/ 8 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec .................~~(,_,"> 2/ 6 sec .................~~(,_,"> 2/ 6 sec .................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec .....................................~~(,_,"> 2/ 3 sec .....................................~~(,_,"> 2/ 3 sec .....................................~~(,_,"> 2/ 3 sec ......................................~~(,_,"> 2/ 3 sec ......................................~~(,_,"> 2/ 3 sec ......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 30.1 degrees; offsets= 10.1 pixels CurrentResolution= 31 Angstroms, which requires orientationSampling of at least 10 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.155736 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000331923 Gb, available memory = 16 Gb. Expectation iteration 1 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 1/ 35 sec .~~(,_,"> 2/ 48 sec ..~~(,_,"> 2/ 37 sec ...~~(,_,"> 3/ 45 sec ...~~(,_,"> 4/ 50 sec ....~~(,_,"> 4/ 43 sec .....~~(,_,"> 5/ 47 sec ......~~(,_,"> 5/ 42 sec .......~~(,_,"> 6/ 45 sec .......~~(,_,"> 6/ 41 sec ........~~(,_,"> 7/ 44 sec .........~~(,_,"> 7/ 41 sec ..........~~(,_,"> 8/ 43 sec ..........~~(,_,"> 9/ 46 sec ...........~~(,_,"> 9/ 43 sec ............~~(,_,"> 10/ 45 sec .............~~(,_,"> 10/ 42 sec ..............~~(,_,"> 11/ 44 sec ..............~~(,_,"> 11/ 42 sec ...............~~(,_,"> 12/ 44 sec ................~~(,_,"> 12/ 42 sec .................~~(,_,"> 13/ 43 sec .................~~(,_,"> 13/ 41 sec ..................~~(,_,"> 13/ 40 sec ...................~~(,_,"> 14/ 41 sec ....................~~(,_,"> 14/ 40 sec ....................~~(,_,"> 15/ 41 sec .....................~~(,_,"> 15/ 40 sec ......................~~(,_,"> 16/ 41 sec .......................~~(,_,"> 16/ 40 sec .......................~~(,_,"> 17/ 41 sec ........................~~(,_,"> 17/ 39 sec .........................~~(,_,"> 18/ 41 sec ..........................~~(,_,"> 18/ 39 sec ...........................~~(,_,"> 18/ 38 sec ...........................~~(,_,"> 19/ 39 sec ............................~~(,_,"> 19/ 38 sec .............................~~(,_,"> 20/ 39 sec ..............................~~(,_,"> 20/ 38 sec ..............................~~(,_,"> 21/ 39 sec ...............................~~(,_,"> 21/ 38 sec ................................~~(,_,"> 22/ 39 sec .................................~~(,_,"> 22/ 38 sec ..................................~~(,_,"> 23/ 39 sec ..................................~~(,_,"> 23/ 38 sec ...................................~~(,_,"> 23/ 38 sec ....................................~~(,_,"> 24/ 38 sec .....................................~~(,_,"> 24/ 38 sec .....................................~~(,_,"> 25/ 38 sec ......................................~~(,_,"> 25/ 38 sec .......................................~~(,_,"> 25/ 37 sec ........................................~~(,_,"> 26/ 38 sec ........................................~~(,_,"> 26/ 37 sec .........................................~~(,_,"> 27/ 38 sec ..........................................~~(,_,"> 27/ 37 sec ...........................................~~(,_,"> 27/ 36 sec ............................................~~(,_,"> 28/ 37 sec ............................................~~(,_,"> 29/ 38 sec .............................................~~(,_,"> 29/ 37 sec ..............................................~~(,_,"> 30/ 38 sec ...............................................~~(,_,"> 30/ 37 sec ...............................................~~(,_,"> 31/ 38 sec ................................................~~(,_,"> 31/ 37 sec .................................................~~(,_,"> 32/ 38 sec ..................................................~~(,_,"> 32/ 37 sec ..................................................~~(,_,"> 33/ 38 sec ...................................................~~(,_,"> 33/ 37 sec ....................................................~~(,_,"> 34/ 38 sec .....................................................~~(,_,"> 34/ 37 sec ......................................................~~(,_,"> 35/ 38 sec ......................................................~~(,_,"> 35/ 37 sec .......................................................~~(,_,"> 35/ 37 sec ........................................................~~(,_,"> 36/ 37 sec .........................................................~~(,_,"> 36/ 37 sec .........................................................~~(,_,"> 37/ 37 sec ..........................................................~~(,_,"> 37/ 37 sec ...........................................................~~(,_,"> 38/ 37 sec ............................................................~~(,_,"> 38/ 38 sec ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 30.1 degrees; offsets= 9.8 pixels CurrentResolution= 86.8 Angstroms, which requires orientationSampling of at least 27.6923 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.139407 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000135183 Gb, available memory = 16 Gb. Expectation iteration 2 of 25 000/??? sec ~~(,_,"> [oo] 0.03/2.17 min ~~(,_,"> 0.07/2.35 min .~~(,_,"> 0.08/2.02 min ..~~(,_,"> 0.12/2.17 min ...~~(,_,"> 0.15/2.25 min ...~~(,_,"> 0.18/2.30 min ....~~(,_,"> 0.20/2.17 min .....~~(,_,"> 0.23/2.22 min ......~~(,_,"> 0.27/2.25 min .......~~(,_,"> 0.28/2.17 min .......~~(,_,"> 0.32/2.20 min ........~~(,_,"> 0.35/2.23 min .........~~(,_,"> 0.38/2.25 min ..........~~(,_,"> 0.42/2.28 min ..........~~(,_,"> 0.43/2.22 min ...........~~(,_,"> 0.47/2.23 min ............~~(,_,"> 0.50/2.27 min .............~~(,_,"> 0.53/2.28 min ..............~~(,_,"> 0.55/2.23 min ..............~~(,_,"> 0.58/2.25 min ...............~~(,_,"> 0.60/2.20 min ................~~(,_,"> 0.63/2.22 min .................~~(,_,"> 0.65/2.18 min .................~~(,_,"> 0.68/2.20 min ..................~~(,_,"> 0.70/2.17 min ...................~~(,_,"> 0.73/2.17 min ....................~~(,_,"> 0.77/2.18 min ....................~~(,_,"> 0.78/2.17 min .....................~~(,_,"> 0.82/2.17 min ......................~~(,_,"> 0.85/2.18 min .......................~~(,_,"> 0.88/2.20 min .......................~~(,_,"> 0.92/2.22 min ........................~~(,_,"> 0.93/2.18 min .........................~~(,_,"> 0.97/2.20 min ..........................~~(,_,"> 1.00/2.20 min ...........................~~(,_,"> 1.02/2.18 min ...........................~~(,_,"> 1.05/2.20 min ............................~~(,_,"> 1.07/2.17 min .............................~~(,_,"> 1.10/2.18 min ..............................~~(,_,"> 1.13/2.18 min ..............................~~(,_,"> 1.17/2.20 min ...............................~~(,_,"> 1.20/2.22 min ................................~~(,_,"> 1.22/2.18 min .................................~~(,_,"> 1.25/2.20 min ..................................~~(,_,"> 1.28/2.20 min ..................................~~(,_,"> 1.30/2.18 min ...................................~~(,_,"> 1.33/2.20 min ....................................~~(,_,"> 1.37/2.20 min .....................................~~(,_,"> 1.40/2.22 min .....................................~~(,_,"> 1.43/2.22 min ......................................~~(,_,"> 1.47/2.23 min .......................................~~(,_,"> 1.48/2.20 min ........................................~~(,_,"> 1.52/2.22 min ........................................~~(,_,"> 1.53/2.20 min .........................................~~(,_,"> 1.57/2.20 min ..........................................~~(,_,"> 1.60/2.22 min ...........................................~~(,_,"> 1.63/2.22 min ............................................~~(,_,"> 1.65/2.20 min ............................................~~(,_,"> 1.68/2.22 min .............................................~~(,_,"> 1.72/2.22 min ..............................................~~(,_,"> 1.73/2.20 min ...............................................~~(,_,"> 1.77/2.20 min ...............................................~~(,_,"> 1.78/2.20 min ................................................~~(,_,"> 1.82/2.20 min .................................................~~(,_,"> 1.85/2.20 min ..................................................~~(,_,"> 1.87/2.18 min ..................................................~~(,_,"> 1.90/2.20 min ...................................................~~(,_,"> 1.93/2.20 min ....................................................~~(,_,"> 1.95/2.18 min .....................................................~~(,_,"> 1.98/2.20 min ......................................................~~(,_,"> 2.02/2.20 min ......................................................~~(,_,"> 2.05/2.20 min .......................................................~~(,_,"> 2.07/2.20 min ........................................................~~(,_,"> 2.10/2.20 min .........................................................~~(,_,"> 2.13/2.20 min .........................................................~~(,_,"> 2.15/2.20 min ..........................................................~~(,_,"> 2.18/2.20 min ...........................................................~~(,_,"> 2.22/2.20 min ............................................................~~(,_,"> 2.22/2.22 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ..........................................................~~(,_,"> 2/ 2 sec ..........................................................~~(,_,"> 2/ 2 sec ..........................................................~~(,_,"> 2/ 2 sec ...........................................................~~(,_,"> 2/ 2 sec ...........................................................~~(,_,"> 2/ 2 sec ...........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 29.1 degrees; offsets= 9.1 pixels CurrentResolution= 86.8 Angstroms, which requires orientationSampling of at least 27.6923 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.139407 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000135183 Gb, available memory = 16 Gb. Expectation iteration 3 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.07/1.62 min ..~~(,_,"> 0.08/1.53 min ...~~(,_,"> 0.12/1.75 min ...~~(,_,"> 0.13/1.67 min ....~~(,_,"> 0.17/1.80 min .....~~(,_,"> 0.18/1.73 min ......~~(,_,"> 0.20/1.68 min .......~~(,_,"> 0.23/1.78 min .......~~(,_,"> 0.25/1.73 min ........~~(,_,"> 0.28/1.80 min .........~~(,_,"> 0.30/1.77 min ..........~~(,_,"> 0.32/1.73 min ..........~~(,_,"> 0.35/1.78 min ...........~~(,_,"> 0.38/1.83 min ............~~(,_,"> 0.40/1.80 min .............~~(,_,"> 0.42/1.78 min ..............~~(,_,"> 0.43/1.75 min ..............~~(,_,"> 0.47/1.80 min ...............~~(,_,"> 0.48/1.77 min ................~~(,_,"> 0.52/1.80 min .................~~(,_,"> 0.53/1.78 min .................~~(,_,"> 0.55/1.77 min ..................~~(,_,"> 0.58/1.80 min ...................~~(,_,"> 0.60/1.78 min ....................~~(,_,"> 0.63/1.80 min ....................~~(,_,"> 0.65/1.78 min .....................~~(,_,"> 0.68/1.82 min ......................~~(,_,"> 0.70/1.80 min .......................~~(,_,"> 0.73/1.83 min .......................~~(,_,"> 0.77/1.85 min ........................~~(,_,"> 0.78/1.83 min .........................~~(,_,"> 0.80/1.82 min ..........................~~(,_,"> 0.83/1.83 min ...........................~~(,_,"> 0.87/1.87 min ...........................~~(,_,"> 0.88/1.85 min ............................~~(,_,"> 0.90/1.83 min .............................~~(,_,"> 0.93/1.85 min ..............................~~(,_,"> 0.95/1.83 min ..............................~~(,_,"> 0.97/1.82 min ...............................~~(,_,"> 1.00/1.83 min ................................~~(,_,"> 1.02/1.83 min .................................~~(,_,"> 1.03/1.82 min ..................................~~(,_,"> 1.07/1.83 min ..................................~~(,_,"> 1.08/1.82 min ...................................~~(,_,"> 1.10/1.82 min ....................................~~(,_,"> 1.13/1.83 min .....................................~~(,_,"> 1.15/1.82 min .....................................~~(,_,"> 1.18/1.83 min ......................................~~(,_,"> 1.22/1.85 min .......................................~~(,_,"> 1.23/1.83 min ........................................~~(,_,"> 1.27/1.85 min ........................................~~(,_,"> 1.28/1.83 min .........................................~~(,_,"> 1.32/1.85 min ..........................................~~(,_,"> 1.33/1.85 min ...........................................~~(,_,"> 1.35/1.83 min ............................................~~(,_,"> 1.37/1.82 min ............................................~~(,_,"> 1.38/1.82 min .............................................~~(,_,"> 1.42/1.83 min ..............................................~~(,_,"> 1.43/1.82 min ...............................................~~(,_,"> 1.45/1.82 min ...............................................~~(,_,"> 1.48/1.82 min ................................................~~(,_,"> 1.50/1.82 min .................................................~~(,_,"> 1.52/1.80 min ..................................................~~(,_,"> 1.55/1.82 min ..................................................~~(,_,"> 1.58/1.83 min ...................................................~~(,_,"> 1.60/1.82 min ....................................................~~(,_,"> 1.62/1.82 min .....................................................~~(,_,"> 1.63/1.80 min ......................................................~~(,_,"> 1.67/1.82 min ......................................................~~(,_,"> 1.68/1.82 min .......................................................~~(,_,"> 1.72/1.82 min ........................................................~~(,_,"> 1.73/1.82 min .........................................................~~(,_,"> 1.77/1.82 min .........................................................~~(,_,"> 1.78/1.82 min ..........................................................~~(,_,"> 1.80/1.82 min ...........................................................~~(,_,"> 1.83/1.82 min ............................................................~~(,_,"> 1.83/1.83 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 25.9 degrees; offsets= 7.6 pixels CurrentResolution= 72.3333 Angstroms, which requires orientationSampling of at least 22.5 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.140851 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000152752 Gb, available memory = 16 Gb. Expectation iteration 4 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.05/1.77 min .~~(,_,"> 0.08/2.02 min ..~~(,_,"> 0.10/1.85 min ...~~(,_,"> 0.12/1.75 min ...~~(,_,"> 0.13/1.67 min ....~~(,_,"> 0.15/1.62 min .....~~(,_,"> 0.18/1.73 min ......~~(,_,"> 0.20/1.68 min .......~~(,_,"> 0.22/1.65 min .......~~(,_,"> 0.25/1.73 min ........~~(,_,"> 0.27/1.70 min .........~~(,_,"> 0.28/1.67 min ..........~~(,_,"> 0.28/1.55 min ..........~~(,_,"> 0.32/1.62 min ...........~~(,_,"> 0.33/1.60 min ............~~(,_,"> 0.35/1.58 min .............~~(,_,"> 0.37/1.57 min ..............~~(,_,"> 0.38/1.55 min ..............~~(,_,"> 0.40/1.53 min ...............~~(,_,"> 0.43/1.58 min ................~~(,_,"> 0.45/1.57 min .................~~(,_,"> 0.47/1.57 min .................~~(,_,"> 0.48/1.55 min ..................~~(,_,"> 0.50/1.53 min ...................~~(,_,"> 0.53/1.58 min ....................~~(,_,"> 0.55/1.57 min ....................~~(,_,"> 0.57/1.57 min .....................~~(,_,"> 0.58/1.55 min ......................~~(,_,"> 0.62/1.58 min .......................~~(,_,"> 0.63/1.58 min .......................~~(,_,"> 0.65/1.57 min ........................~~(,_,"> 0.67/1.55 min .........................~~(,_,"> 0.70/1.58 min ..........................~~(,_,"> 0.72/1.58 min ...........................~~(,_,"> 0.73/1.57 min ...........................~~(,_,"> 0.75/1.57 min ............................~~(,_,"> 0.77/1.55 min .............................~~(,_,"> 0.78/1.55 min ..............................~~(,_,"> 0.82/1.58 min ..............................~~(,_,"> 0.83/1.57 min ...............................~~(,_,"> 0.85/1.57 min ................................~~(,_,"> 0.87/1.55 min .................................~~(,_,"> 0.88/1.55 min ..................................~~(,_,"> 0.92/1.57 min ..................................~~(,_,"> 0.93/1.57 min ...................................~~(,_,"> 0.95/1.57 min ....................................~~(,_,"> 0.97/1.55 min .....................................~~(,_,"> 0.98/1.55 min .....................................~~(,_,"> 1.02/1.57 min ......................................~~(,_,"> 1.05/1.58 min .......................................~~(,_,"> 1.07/1.58 min ........................................~~(,_,"> 1.10/1.60 min ........................................~~(,_,"> 1.12/1.60 min .........................................~~(,_,"> 1.15/1.62 min ..........................................~~(,_,"> 1.17/1.62 min ...........................................~~(,_,"> 1.18/1.60 min ............................................~~(,_,"> 1.22/1.62 min ............................................~~(,_,"> 1.22/1.60 min .............................................~~(,_,"> 1.25/1.62 min ..............................................~~(,_,"> 1.27/1.60 min ...............................................~~(,_,"> 1.28/1.60 min ...............................................~~(,_,"> 1.30/1.60 min ................................................~~(,_,"> 1.33/1.62 min .................................................~~(,_,"> 1.35/1.60 min ..................................................~~(,_,"> 1.38/1.62 min ..................................................~~(,_,"> 1.40/1.62 min ...................................................~~(,_,"> 1.42/1.62 min ....................................................~~(,_,"> 1.43/1.60 min .....................................................~~(,_,"> 1.47/1.62 min ......................................................~~(,_,"> 1.48/1.62 min ......................................................~~(,_,"> 1.50/1.62 min .......................................................~~(,_,"> 1.52/1.60 min ........................................................~~(,_,"> 1.53/1.60 min .........................................................~~(,_,"> 1.55/1.60 min .........................................................~~(,_,"> 1.58/1.62 min ..........................................................~~(,_,"> 1.60/1.60 min ...........................................................~~(,_,"> 1.62/1.60 min ............................................................~~(,_,"> 1.63/1.63 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ...............................~~(,_,"> 0/ 0 sec ...............................~~(,_,"> 0/ 0 sec ...............................~~(,_,"> 0/ 0 sec ................................~~(,_,"> 0/ 0 sec ................................~~(,_,"> 0/ 0 sec ................................~~(,_,"> 0/ 0 sec .................................~~(,_,"> 0/ 0 sec .................................~~(,_,"> 0/ 0 sec .................................~~(,_,"> 0/ 0 sec .................................~~(,_,"> 0/ 0 sec ..................................~~(,_,"> 0/ 0 sec ..................................~~(,_,"> 0/ 0 sec ..................................~~(,_,"> 0/ 0 sec ...................................~~(,_,"> 0/ 0 sec ...................................~~(,_,"> 0/ 0 sec ...................................~~(,_,"> 0/ 0 sec ....................................~~(,_,"> 0/ 0 sec ....................................~~(,_,"> 0/ 0 sec ....................................~~(,_,"> 0/ 0 sec ....................................~~(,_,"> 0/ 0 sec .....................................~~(,_,"> 0/ 0 sec .....................................~~(,_,"> 0/ 0 sec .....................................~~(,_,"> 0/ 0 sec ......................................~~(,_,"> 0/ 0 sec ......................................~~(,_,"> 0/ 0 sec ......................................~~(,_,"> 0/ 0 sec .......................................~~(,_,"> 0/ 0 sec .......................................~~(,_,"> 0/ 0 sec .......................................~~(,_,"> 0/ 0 sec .......................................~~(,_,"> 0/ 0 sec ........................................~~(,_,"> 0/ 0 sec ........................................~~(,_,"> 0/ 0 sec ........................................~~(,_,"> 0/ 0 sec .........................................~~(,_,"> 0/ 0 sec .........................................~~(,_,"> 0/ 0 sec .........................................~~(,_,"> 0/ 0 sec ..........................................~~(,_,"> 0/ 0 sec ..........................................~~(,_,"> 0/ 0 sec ..........................................~~(,_,"> 0/ 0 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 17 degrees; offsets= 6.25 pixels CurrentResolution= 62 Angstroms, which requires orientationSampling of at least 20 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.142388 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000171393 Gb, available memory = 16 Gb. Expectation iteration 5 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.07/1.62 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.12/1.47 min ....~~(,_,"> 0.13/1.43 min .....~~(,_,"> 0.15/1.42 min ......~~(,_,"> 0.17/1.40 min .......~~(,_,"> 0.18/1.40 min .......~~(,_,"> 0.20/1.38 min ........~~(,_,"> 0.23/1.48 min .........~~(,_,"> 0.25/1.47 min ..........~~(,_,"> 0.27/1.45 min ..........~~(,_,"> 0.28/1.45 min ...........~~(,_,"> 0.30/1.43 min ............~~(,_,"> 0.32/1.43 min .............~~(,_,"> 0.33/1.42 min ..............~~(,_,"> 0.35/1.42 min ..............~~(,_,"> 0.37/1.40 min ...............~~(,_,"> 0.38/1.40 min ................~~(,_,"> 0.40/1.40 min .................~~(,_,"> 0.42/1.40 min .................~~(,_,"> 0.43/1.38 min ..................~~(,_,"> 0.45/1.38 min ...................~~(,_,"> 0.47/1.38 min ....................~~(,_,"> 0.48/1.38 min ....................~~(,_,"> 0.50/1.37 min .....................~~(,_,"> 0.52/1.37 min ......................~~(,_,"> 0.55/1.42 min .......................~~(,_,"> 0.57/1.42 min .......................~~(,_,"> 0.58/1.40 min ........................~~(,_,"> 0.60/1.40 min .........................~~(,_,"> 0.62/1.40 min ..........................~~(,_,"> 0.63/1.40 min ...........................~~(,_,"> 0.65/1.40 min ...........................~~(,_,"> 0.67/1.38 min ............................~~(,_,"> 0.68/1.38 min .............................~~(,_,"> 0.70/1.38 min ..............................~~(,_,"> 0.72/1.38 min ..............................~~(,_,"> 0.73/1.38 min ...............................~~(,_,"> 0.75/1.38 min ................................~~(,_,"> 0.77/1.38 min .................................~~(,_,"> 0.78/1.37 min ..................................~~(,_,"> 0.82/1.40 min ..................................~~(,_,"> 0.83/1.40 min ...................................~~(,_,"> 0.83/1.37 min ....................................~~(,_,"> 0.85/1.37 min .....................................~~(,_,"> 0.88/1.40 min .....................................~~(,_,"> 0.90/1.38 min ......................................~~(,_,"> 0.92/1.38 min .......................................~~(,_,"> 0.93/1.38 min ........................................~~(,_,"> 0.95/1.38 min ........................................~~(,_,"> 0.97/1.38 min .........................................~~(,_,"> 1.00/1.40 min ..........................................~~(,_,"> 1.00/1.38 min ...........................................~~(,_,"> 1.02/1.38 min ............................................~~(,_,"> 1.03/1.38 min ............................................~~(,_,"> 1.07/1.40 min .............................................~~(,_,"> 1.08/1.40 min ..............................................~~(,_,"> 1.10/1.40 min ...............................................~~(,_,"> 1.12/1.40 min ...............................................~~(,_,"> 1.13/1.38 min ................................................~~(,_,"> 1.15/1.38 min .................................................~~(,_,"> 1.17/1.38 min ..................................................~~(,_,"> 1.20/1.40 min ..................................................~~(,_,"> 1.22/1.40 min ...................................................~~(,_,"> 1.22/1.38 min ....................................................~~(,_,"> 1.23/1.38 min .....................................................~~(,_,"> 1.27/1.40 min ......................................................~~(,_,"> 1.27/1.38 min ......................................................~~(,_,"> 1.30/1.40 min .......................................................~~(,_,"> 1.32/1.40 min ........................................................~~(,_,"> 1.33/1.40 min .........................................................~~(,_,"> 1.35/1.40 min .........................................................~~(,_,"> 1.37/1.38 min ..........................................................~~(,_,"> 1.38/1.38 min ...........................................................~~(,_,"> 1.40/1.38 min ............................................................~~(,_,"> 1.40/1.40 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ..........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ...........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 12.2 degrees; offsets= 4.85 pixels CurrentResolution= 62 Angstroms, which requires orientationSampling of at least 20 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.142388 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000171393 Gb, available memory = 16 Gb. Expectation iteration 6 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 4/ 60 sec ...~~(,_,"> 0.08/1.03 min ....~~(,_,"> 0.10/1.08 min .....~~(,_,"> 0.12/1.10 min ......~~(,_,"> 7/ 59 sec .......~~(,_,"> 0.15/1.13 min .......~~(,_,"> 0.17/1.15 min ........~~(,_,"> 0.17/1.05 min .........~~(,_,"> 0.18/1.08 min ..........~~(,_,"> 0.20/1.08 min ..........~~(,_,"> 0.22/1.10 min ...........~~(,_,"> 0.23/1.12 min ............~~(,_,"> 0.23/1.05 min .............~~(,_,"> 0.25/1.07 min ..............~~(,_,"> 0.27/1.08 min ..............~~(,_,"> 0.28/1.08 min ...............~~(,_,"> 0.30/1.10 min ................~~(,_,"> 0.32/1.10 min .................~~(,_,"> 0.32/1.05 min .................~~(,_,"> 0.33/1.07 min ..................~~(,_,"> 0.35/1.08 min ...................~~(,_,"> 0.37/1.08 min ....................~~(,_,"> 0.38/1.08 min ....................~~(,_,"> 0.40/1.10 min .....................~~(,_,"> 0.42/1.10 min ......................~~(,_,"> 0.43/1.12 min .......................~~(,_,"> 0.45/1.12 min .......................~~(,_,"> 0.45/1.08 min ........................~~(,_,"> 0.47/1.08 min .........................~~(,_,"> 0.48/1.10 min ..........................~~(,_,"> 0.50/1.10 min ...........................~~(,_,"> 0.52/1.10 min ...........................~~(,_,"> 0.53/1.12 min ............................~~(,_,"> 0.53/1.08 min .............................~~(,_,"> 0.55/1.08 min ..............................~~(,_,"> 0.57/1.08 min ..............................~~(,_,"> 0.58/1.10 min ...............................~~(,_,"> 0.60/1.10 min ................................~~(,_,"> 0.62/1.10 min .................................~~(,_,"> 0.63/1.12 min ..................................~~(,_,"> 0.65/1.12 min ..................................~~(,_,"> 0.67/1.12 min ...................................~~(,_,"> 0.67/1.10 min ....................................~~(,_,"> 0.68/1.10 min .....................................~~(,_,"> 0.70/1.10 min .....................................~~(,_,"> 0.72/1.10 min ......................................~~(,_,"> 0.72/1.08 min .......................................~~(,_,"> 0.73/1.08 min ........................................~~(,_,"> 0.75/1.08 min ........................................~~(,_,"> 0.77/1.10 min .........................................~~(,_,"> 0.78/1.10 min ..........................................~~(,_,"> 0.78/1.08 min ...........................................~~(,_,"> 0.80/1.08 min ............................................~~(,_,"> 0.82/1.08 min ............................................~~(,_,"> 0.83/1.08 min .............................................~~(,_,"> 0.85/1.10 min ..............................................~~(,_,"> 0.87/1.10 min ...............................................~~(,_,"> 0.88/1.10 min ...............................................~~(,_,"> 0.90/1.10 min ................................................~~(,_,"> 0.90/1.08 min .................................................~~(,_,"> 0.92/1.08 min ..................................................~~(,_,"> 0.93/1.08 min ..................................................~~(,_,"> 0.93/1.08 min ...................................................~~(,_,"> 0.95/1.08 min ....................................................~~(,_,"> 0.97/1.08 min .....................................................~~(,_,"> 0.98/1.08 min ......................................................~~(,_,"> 1.00/1.08 min ......................................................~~(,_,"> 1.02/1.08 min .......................................................~~(,_,"> 1.03/1.10 min ........................................................~~(,_,"> 1.05/1.10 min .........................................................~~(,_,"> 1.07/1.10 min .........................................................~~(,_,"> 1.08/1.10 min ..........................................................~~(,_,"> 1.10/1.10 min ...........................................................~~(,_,"> 1.10/1.08 min ............................................................~~(,_,"> 1.12/1.12 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 7.45 degrees; offsets= 3.9 pixels CurrentResolution= 54.25 Angstroms, which requires orientationSampling of at least 17.1429 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.144017 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000191107 Gb, available memory = 16 Gb. Expectation iteration 7 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 1/ 35 sec .~~(,_,"> 2/ 48 sec ..~~(,_,"> 3/ 55 sec ...~~(,_,"> 4/ 60 sec ...~~(,_,"> 0.08/1.03 min ....~~(,_,"> 0.10/1.08 min .....~~(,_,"> 6/ 57 sec ......~~(,_,"> 7/ 59 sec .......~~(,_,"> 0.13/1.02 min .......~~(,_,"> 0.15/1.03 min ........~~(,_,"> 9/ 57 sec .........~~(,_,"> 10/ 59 sec ..........~~(,_,"> 11/ 60 sec ..........~~(,_,"> 0.20/1.02 min ...........~~(,_,"> 12/ 57 sec ............~~(,_,"> 13/ 58 sec .............~~(,_,"> 13/ 55 sec ..............~~(,_,"> 14/ 56 sec ..............~~(,_,"> 15/ 57 sec ...............~~(,_,"> 16/ 58 sec ................~~(,_,"> 17/ 59 sec .................~~(,_,"> 18/ 60 sec .................~~(,_,"> 18/ 58 sec ..................~~(,_,"> 19/ 58 sec ...................~~(,_,"> 20/ 59 sec ....................~~(,_,"> 21/ 60 sec ....................~~(,_,"> 22/ 60 sec .....................~~(,_,"> 0.38/1.02 min ......................~~(,_,"> 0.40/1.02 min .......................~~(,_,"> 24/ 60 sec .......................~~(,_,"> 0.43/1.03 min ........................~~(,_,"> 0.45/1.05 min .........................~~(,_,"> 0.47/1.05 min ..........................~~(,_,"> 0.47/1.03 min ...........................~~(,_,"> 0.48/1.03 min ...........................~~(,_,"> 0.50/1.03 min ............................~~(,_,"> 0.52/1.05 min .............................~~(,_,"> 0.53/1.05 min ..............................~~(,_,"> 0.55/1.07 min ..............................~~(,_,"> 0.57/1.07 min ...............................~~(,_,"> 0.58/1.07 min ................................~~(,_,"> 0.58/1.05 min .................................~~(,_,"> 0.60/1.05 min ..................................~~(,_,"> 0.62/1.05 min ..................................~~(,_,"> 0.62/1.03 min ...................................~~(,_,"> 0.65/1.07 min ....................................~~(,_,"> 0.65/1.05 min .....................................~~(,_,"> 0.67/1.05 min .....................................~~(,_,"> 0.68/1.05 min ......................................~~(,_,"> 0.70/1.05 min .......................................~~(,_,"> 0.72/1.07 min ........................................~~(,_,"> 0.72/1.05 min ........................................~~(,_,"> 0.73/1.05 min .........................................~~(,_,"> 0.75/1.05 min ..........................................~~(,_,"> 0.77/1.05 min ...........................................~~(,_,"> 0.78/1.07 min ............................................~~(,_,"> 0.80/1.07 min ............................................~~(,_,"> 0.82/1.07 min .............................................~~(,_,"> 0.83/1.07 min ..............................................~~(,_,"> 0.83/1.05 min ...............................................~~(,_,"> 0.85/1.05 min ...............................................~~(,_,"> 0.87/1.07 min ................................................~~(,_,"> 0.88/1.07 min .................................................~~(,_,"> 0.90/1.07 min ..................................................~~(,_,"> 0.92/1.07 min ..................................................~~(,_,"> 0.92/1.05 min ...................................................~~(,_,"> 0.93/1.07 min ....................................................~~(,_,"> 0.95/1.07 min .....................................................~~(,_,"> 0.97/1.07 min ......................................................~~(,_,"> 0.98/1.07 min ......................................................~~(,_,"> 1.00/1.07 min .......................................................~~(,_,"> 1.02/1.08 min ........................................................~~(,_,"> 1.03/1.08 min .........................................................~~(,_,"> 1.05/1.08 min .........................................................~~(,_,"> 1.05/1.07 min ..........................................................~~(,_,"> 1.07/1.07 min ...........................................................~~(,_,"> 1.10/1.08 min ............................................................~~(,_,"> 1.10/1.10 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 4.35 degrees; offsets= 3 pixels CurrentResolution= 48.2222 Angstroms, which requires orientationSampling of at least 15.6522 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.145739 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000211895 Gb, available memory = 16 Gb. Expectation iteration 8 of 25 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 1/ 35 sec .~~(,_,"> 2/ 48 sec ..~~(,_,"> 3/ 55 sec ...~~(,_,"> 4/ 60 sec ...~~(,_,"> 0.08/1.03 min ....~~(,_,"> 0.10/1.08 min .....~~(,_,"> 6/ 57 sec ......~~(,_,"> 7/ 59 sec .......~~(,_,"> 0.13/1.02 min .......~~(,_,"> 0.15/1.03 min ........~~(,_,"> 9/ 57 sec .........~~(,_,"> 10/ 59 sec ..........~~(,_,"> 11/ 60 sec ..........~~(,_,"> 0.20/1.02 min ...........~~(,_,"> 0.22/1.03 min ............~~(,_,"> 0.23/1.05 min .............~~(,_,"> 0.25/1.07 min ..............~~(,_,"> 0.27/1.08 min ..............~~(,_,"> 0.28/1.08 min ...............~~(,_,"> 0.30/1.10 min ................~~(,_,"> 0.32/1.10 min .................~~(,_,"> 0.33/1.12 min .................~~(,_,"> 0.35/1.12 min ..................~~(,_,"> 0.35/1.08 min ...................~~(,_,"> 0.37/1.08 min ....................~~(,_,"> 0.38/1.08 min ....................~~(,_,"> 0.40/1.10 min .....................~~(,_,"> 0.42/1.10 min ......................~~(,_,"> 0.42/1.07 min .......................~~(,_,"> 0.43/1.08 min .......................~~(,_,"> 0.45/1.08 min ........................~~(,_,"> 0.45/1.05 min .........................~~(,_,"> 0.47/1.05 min ..........................~~(,_,"> 0.48/1.07 min ...........................~~(,_,"> 0.50/1.07 min ...........................~~(,_,"> 0.50/1.03 min ............................~~(,_,"> 0.52/1.05 min .............................~~(,_,"> 0.53/1.05 min ..............................~~(,_,"> 0.55/1.07 min ..............................~~(,_,"> 0.57/1.07 min ...............................~~(,_,"> 0.58/1.07 min ................................~~(,_,"> 0.58/1.05 min .................................~~(,_,"> 0.60/1.05 min ..................................~~(,_,"> 0.62/1.05 min ..................................~~(,_,"> 0.63/1.07 min ...................................~~(,_,"> 0.65/1.07 min ....................................~~(,_,"> 0.67/1.07 min .....................................~~(,_,"> 0.68/1.08 min .....................................~~(,_,"> 0.70/1.08 min ......................................~~(,_,"> 0.72/1.08 min .......................................~~(,_,"> 0.73/1.08 min ........................................~~(,_,"> 0.73/1.07 min ........................................~~(,_,"> 0.77/1.10 min .........................................~~(,_,"> 0.77/1.08 min ..........................................~~(,_,"> 0.80/1.10 min ...........................................~~(,_,"> 0.82/1.10 min ............................................~~(,_,"> 0.82/1.08 min ............................................~~(,_,"> 0.83/1.08 min .............................................~~(,_,"> 0.85/1.10 min ..............................................~~(,_,"> 0.85/1.08 min ...............................................~~(,_,"> 0.87/1.08 min ...............................................~~(,_,"> 0.88/1.08 min ................................................~~(,_,"> 0.90/1.08 min .................................................~~(,_,"> 0.92/1.08 min ..................................................~~(,_,"> 0.92/1.07 min ..................................................~~(,_,"> 0.93/1.08 min ...................................................~~(,_,"> 0.95/1.08 min ....................................................~~(,_,"> 0.97/1.08 min .....................................................~~(,_,"> 0.98/1.08 min ......................................................~~(,_,"> 1.00/1.08 min ......................................................~~(,_,"> 1.00/1.07 min .......................................................~~(,_,"> 1.02/1.08 min ........................................................~~(,_,"> 1.03/1.08 min .........................................................~~(,_,"> 1.03/1.07 min .........................................................~~(,_,"> 1.05/1.07 min ..........................................................~~(,_,"> 1.07/1.07 min ...........................................................~~(,_,"> 1.08/1.07 min ............................................................~~(,_,"> 1.10/1.10 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec .....................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec ......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.4 degrees; offsets= 2.05 pixels CurrentResolution= 43.4 Angstroms, which requires orientationSampling of at least 13.8462 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.147553 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000233755 Gb, available memory = 16 Gb. Expectation iteration 9 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 3/ 55 sec ...~~(,_,"> 4/ 60 sec ...~~(,_,"> 0.08/1.03 min ....~~(,_,"> 0.10/1.08 min .....~~(,_,"> 0.12/1.10 min ......~~(,_,"> 0.13/1.12 min .......~~(,_,"> 0.13/1.02 min .......~~(,_,"> 0.17/1.15 min ........~~(,_,"> 0.17/1.05 min .........~~(,_,"> 0.20/1.17 min ..........~~(,_,"> 0.20/1.08 min ..........~~(,_,"> 0.22/1.10 min ...........~~(,_,"> 0.23/1.12 min ............~~(,_,"> 0.25/1.13 min .............~~(,_,"> 0.27/1.13 min ..............~~(,_,"> 0.27/1.08 min ..............~~(,_,"> 0.28/1.08 min ...............~~(,_,"> 0.30/1.10 min ................~~(,_,"> 0.32/1.10 min .................~~(,_,"> 0.32/1.05 min .................~~(,_,"> 0.33/1.07 min ..................~~(,_,"> 0.35/1.08 min ...................~~(,_,"> 0.37/1.08 min ....................~~(,_,"> 0.38/1.08 min ....................~~(,_,"> 0.38/1.05 min .....................~~(,_,"> 0.40/1.07 min ......................~~(,_,"> 0.42/1.07 min .......................~~(,_,"> 0.43/1.08 min .......................~~(,_,"> 0.43/1.03 min ........................~~(,_,"> 0.45/1.05 min .........................~~(,_,"> 0.47/1.05 min ..........................~~(,_,"> 0.47/1.03 min ...........................~~(,_,"> 0.48/1.03 min ...........................~~(,_,"> 29/ 60 sec ............................~~(,_,"> 0.50/1.02 min .............................~~(,_,"> 30/ 59 sec ..............................~~(,_,"> 31/ 60 sec ..............................~~(,_,"> 32/ 60 sec ...............................~~(,_,"> 32/ 59 sec ................................~~(,_,"> 33/ 59 sec .................................~~(,_,"> 34/ 60 sec ..................................~~(,_,"> 34/ 58 sec ..................................~~(,_,"> 35/ 59 sec ...................................~~(,_,"> 36/ 59 sec ....................................~~(,_,"> 37/ 59 sec .....................................~~(,_,"> 37/ 58 sec .....................................~~(,_,"> 38/ 59 sec ......................................~~(,_,"> 39/ 59 sec .......................................~~(,_,"> 39/ 58 sec ........................................~~(,_,"> 40/ 58 sec ........................................~~(,_,"> 41/ 59 sec .........................................~~(,_,"> 41/ 57 sec ..........................................~~(,_,"> 42/ 58 sec ...........................................~~(,_,"> 43/ 58 sec ............................................~~(,_,"> 44/ 58 sec ............................................~~(,_,"> 44/ 57 sec .............................................~~(,_,"> 45/ 58 sec ..............................................~~(,_,"> 46/ 58 sec ...............................................~~(,_,"> 46/ 57 sec ...............................................~~(,_,"> 47/ 58 sec ................................................~~(,_,"> 47/ 57 sec .................................................~~(,_,"> 48/ 57 sec ..................................................~~(,_,"> 49/ 57 sec ..................................................~~(,_,"> 49/ 56 sec ...................................................~~(,_,"> 50/ 57 sec ....................................................~~(,_,"> 50/ 56 sec .....................................................~~(,_,"> 51/ 56 sec ......................................................~~(,_,"> 52/ 56 sec ......................................................~~(,_,"> 52/ 56 sec .......................................................~~(,_,"> 53/ 56 sec ........................................................~~(,_,"> 54/ 56 sec .........................................................~~(,_,"> 54/ 56 sec .........................................................~~(,_,"> 55/ 56 sec ..........................................................~~(,_,"> 55/ 55 sec ...........................................................~~(,_,"> 56/ 55 sec ............................................................~~(,_,"> 56/ 56 sec ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec .......................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec ........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec .........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ..........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ...........................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec ............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec .............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ..............................~~(,_,"> 0/ 0 sec ...............................~~(,_,"> 0/ 0 sec ...............................~~(,_,"> 0/ 0 sec ...............................~~(,_,"> 0/ 0 sec ................................~~(,_,"> 0/ 0 sec ................................~~(,_,"> 0/ 0 sec ................................~~(,_,"> 0/ 0 sec .................................~~(,_,"> 0/ 0 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 4.1 degrees; offsets= 2.81 pixels CurrentResolution= 39.4545 Angstroms, which requires orientationSampling of at least 12.8571 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.14946 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000256687 Gb, available memory = 16 Gb. Expectation iteration 10 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 1/ 35 sec .~~(,_,"> 2/ 48 sec ..~~(,_,"> 3/ 55 sec ...~~(,_,"> 3/ 45 sec ...~~(,_,"> 4/ 50 sec ....~~(,_,"> 4/ 43 sec .....~~(,_,"> 6/ 57 sec ......~~(,_,"> 6/ 50 sec .......~~(,_,"> 7/ 53 sec .......~~(,_,"> 7/ 48 sec ........~~(,_,"> 8/ 51 sec .........~~(,_,"> 9/ 53 sec ..........~~(,_,"> 9/ 49 sec ..........~~(,_,"> 10/ 51 sec ...........~~(,_,"> 10/ 48 sec ............~~(,_,"> 11/ 49 sec .............~~(,_,"> 11/ 47 sec ..............~~(,_,"> 12/ 48 sec ..............~~(,_,"> 13/ 50 sec ...............~~(,_,"> 13/ 47 sec ................~~(,_,"> 14/ 49 sec .................~~(,_,"> 14/ 47 sec .................~~(,_,"> 15/ 48 sec ..................~~(,_,"> 16/ 49 sec ...................~~(,_,"> 16/ 47 sec ....................~~(,_,"> 17/ 48 sec ....................~~(,_,"> 18/ 49 sec .....................~~(,_,"> 18/ 48 sec ......................~~(,_,"> 19/ 49 sec .......................~~(,_,"> 20/ 50 sec .......................~~(,_,"> 20/ 48 sec ........................~~(,_,"> 21/ 49 sec .........................~~(,_,"> 21/ 47 sec ..........................~~(,_,"> 22/ 48 sec ...........................~~(,_,"> 23/ 49 sec ...........................~~(,_,"> 23/ 48 sec ............................~~(,_,"> 24/ 49 sec .............................~~(,_,"> 25/ 49 sec ..............................~~(,_,"> 25/ 48 sec ..............................~~(,_,"> 26/ 49 sec ...............................~~(,_,"> 26/ 48 sec ................................~~(,_,"> 27/ 48 sec .................................~~(,_,"> 27/ 47 sec ..................................~~(,_,"> 28/ 48 sec ..................................~~(,_,"> 29/ 48 sec ...................................~~(,_,"> 29/ 47 sec ....................................~~(,_,"> 30/ 48 sec .....................................~~(,_,"> 31/ 49 sec .....................................~~(,_,"> 31/ 48 sec ......................................~~(,_,"> 32/ 48 sec .......................................~~(,_,"> 33/ 49 sec ........................................~~(,_,"> 33/ 48 sec ........................................~~(,_,"> 34/ 48 sec .........................................~~(,_,"> 34/ 48 sec ..........................................~~(,_,"> 35/ 48 sec ...........................................~~(,_,"> 35/ 47 sec ............................................~~(,_,"> 36/ 48 sec ............................................~~(,_,"> 36/ 47 sec .............................................~~(,_,"> 37/ 47 sec ..............................................~~(,_,"> 38/ 48 sec ...............................................~~(,_,"> 38/ 47 sec ...............................................~~(,_,"> 39/ 48 sec ................................................~~(,_,"> 39/ 47 sec .................................................~~(,_,"> 40/ 47 sec ..................................................~~(,_,"> 41/ 48 sec ..................................................~~(,_,"> 41/ 47 sec ...................................................~~(,_,"> 42/ 48 sec ....................................................~~(,_,"> 42/ 47 sec .....................................................~~(,_,"> 43/ 47 sec ......................................................~~(,_,"> 43/ 47 sec ......................................................~~(,_,"> 44/ 47 sec .......................................................~~(,_,"> 44/ 46 sec ........................................................~~(,_,"> 45/ 47 sec .........................................................~~(,_,"> 46/ 47 sec .........................................................~~(,_,"> 46/ 47 sec ..........................................................~~(,_,"> 47/ 47 sec ...........................................................~~(,_,"> 47/ 46 sec ............................................................~~(,_,"> 48/ 48 sec ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 3.55 degrees; offsets= 2.42 pixels CurrentResolution= 36.1667 Angstroms, which requires orientationSampling of at least 11.6129 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.15146 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000280693 Gb, available memory = 16 Gb. Expectation iteration 11 of 25 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 1/ 35 sec .~~(,_,"> 2/ 48 sec ..~~(,_,"> 2/ 37 sec ...~~(,_,"> 3/ 45 sec ...~~(,_,"> 4/ 50 sec ....~~(,_,"> 4/ 43 sec .....~~(,_,"> 5/ 47 sec ......~~(,_,"> 6/ 50 sec .......~~(,_,"> 7/ 53 sec .......~~(,_,"> 7/ 48 sec ........~~(,_,"> 8/ 51 sec .........~~(,_,"> 9/ 53 sec ..........~~(,_,"> 9/ 49 sec ..........~~(,_,"> 10/ 51 sec ...........~~(,_,"> 11/ 52 sec ............~~(,_,"> 11/ 49 sec .............~~(,_,"> 12/ 51 sec ..............~~(,_,"> 12/ 48 sec ..............~~(,_,"> 13/ 50 sec ...............~~(,_,"> 14/ 51 sec ................~~(,_,"> 15/ 52 sec .................~~(,_,"> 15/ 50 sec .................~~(,_,"> 16/ 51 sec ..................~~(,_,"> 17/ 52 sec ...................~~(,_,"> 17/ 50 sec ....................~~(,_,"> 18/ 51 sec ....................~~(,_,"> 18/ 49 sec .....................~~(,_,"> 19/ 50 sec ......................~~(,_,"> 19/ 49 sec .......................~~(,_,"> 20/ 50 sec .......................~~(,_,"> 20/ 48 sec ........................~~(,_,"> 21/ 49 sec .........................~~(,_,"> 22/ 50 sec ..........................~~(,_,"> 22/ 48 sec ...........................~~(,_,"> 23/ 49 sec ...........................~~(,_,"> 23/ 48 sec ............................~~(,_,"> 24/ 49 sec .............................~~(,_,"> 24/ 47 sec ..............................~~(,_,"> 25/ 48 sec ..............................~~(,_,"> 26/ 49 sec ...............................~~(,_,"> 26/ 48 sec ................................~~(,_,"> 27/ 48 sec .................................~~(,_,"> 27/ 47 sec ..................................~~(,_,"> 28/ 48 sec ..................................~~(,_,"> 28/ 47 sec ...................................~~(,_,"> 29/ 47 sec ....................................~~(,_,"> 29/ 46 sec .....................................~~(,_,"> 30/ 47 sec .....................................~~(,_,"> 31/ 48 sec ......................................~~(,_,"> 31/ 47 sec .......................................~~(,_,"> 32/ 47 sec ........................................~~(,_,"> 33/ 48 sec ........................................~~(,_,"> 33/ 47 sec .........................................~~(,_,"> 34/ 48 sec ..........................................~~(,_,"> 34/ 47 sec ...........................................~~(,_,"> 35/ 47 sec ............................................~~(,_,"> 36/ 48 sec ............................................~~(,_,"> 36/ 47 sec .............................................~~(,_,"> 37/ 47 sec ..............................................~~(,_,"> 37/ 47 sec ...............................................~~(,_,"> 38/ 47 sec ...............................................~~(,_,"> 38/ 46 sec ................................................~~(,_,"> 39/ 47 sec .................................................~~(,_,"> 39/ 46 sec ..................................................~~(,_,"> 40/ 47 sec ..................................................~~(,_,"> 41/ 47 sec ...................................................~~(,_,"> 41/ 46 sec ....................................................~~(,_,"> 42/ 47 sec .....................................................~~(,_,"> 42/ 46 sec ......................................................~~(,_,"> 43/ 47 sec ......................................................~~(,_,"> 43/ 46 sec .......................................................~~(,_,"> 44/ 46 sec ........................................................~~(,_,"> 44/ 46 sec .........................................................~~(,_,"> 45/ 46 sec .........................................................~~(,_,"> 46/ 47 sec ..........................................................~~(,_,"> 46/ 46 sec ...........................................................~~(,_,"> 47/ 46 sec ............................................................~~(,_,"> 47/ 47 sec ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec .................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ..................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ...................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec ....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec .....................~~(,_,"> 0/ 0 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec .............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ..............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ...............................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec ................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec .................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ..................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ...................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec ....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec .....................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec ......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec .......................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec ........................................................~~(,_,"> 1/ 1 sec .........................................................~~(,_,"> 1/ 1 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 3.4 degrees; offsets= 2.38 pixels CurrentResolution= 31 Angstroms, which requires orientationSampling of at least 10 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.155736 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000331923 Gb, available memory = 16 Gb. Expectation iteration 12 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 2/ 48 sec ..~~(,_,"> 3/ 55 sec ...~~(,_,"> 4/ 60 sec ...~~(,_,"> 4/ 50 sec ....~~(,_,"> 5/ 54 sec .....~~(,_,"> 6/ 57 sec ......~~(,_,"> 7/ 59 sec .......~~(,_,"> 0.13/1.02 min .......~~(,_,"> 8/ 55 sec ........~~(,_,"> 9/ 57 sec .........~~(,_,"> 10/ 59 sec ..........~~(,_,"> 11/ 60 sec ..........~~(,_,"> 11/ 56 sec ...........~~(,_,"> 12/ 57 sec ............~~(,_,"> 13/ 58 sec .............~~(,_,"> 13/ 55 sec ..............~~(,_,"> 14/ 56 sec ..............~~(,_,"> 15/ 57 sec ...............~~(,_,"> 15/ 55 sec ................~~(,_,"> 16/ 56 sec .................~~(,_,"> 16/ 53 sec .................~~(,_,"> 17/ 54 sec ..................~~(,_,"> 17/ 52 sec ...................~~(,_,"> 18/ 53 sec ....................~~(,_,"> 19/ 54 sec ....................~~(,_,"> 19/ 52 sec .....................~~(,_,"> 20/ 53 sec ......................~~(,_,"> 21/ 54 sec .......................~~(,_,"> 21/ 52 sec .......................~~(,_,"> 22/ 53 sec ........................~~(,_,"> 22/ 51 sec .........................~~(,_,"> 23/ 52 sec ..........................~~(,_,"> 23/ 50 sec ...........................~~(,_,"> 24/ 51 sec ...........................~~(,_,"> 25/ 52 sec ............................~~(,_,"> 25/ 51 sec .............................~~(,_,"> 26/ 51 sec ..............................~~(,_,"> 27/ 52 sec ..............................~~(,_,"> 27/ 51 sec ...............................~~(,_,"> 28/ 51 sec ................................~~(,_,"> 28/ 50 sec .................................~~(,_,"> 29/ 51 sec ..................................~~(,_,"> 30/ 51 sec ..................................~~(,_,"> 30/ 50 sec ...................................~~(,_,"> 31/ 51 sec ....................................~~(,_,"> 32/ 51 sec .....................................~~(,_,"> 33/ 52 sec .....................................~~(,_,"> 33/ 51 sec ......................................~~(,_,"> 34/ 51 sec .......................................~~(,_,"> 35/ 52 sec ........................................~~(,_,"> 35/ 51 sec ........................................~~(,_,"> 36/ 51 sec .........................................~~(,_,"> 37/ 52 sec ..........................................~~(,_,"> 37/ 51 sec ...........................................~~(,_,"> 38/ 51 sec ............................................~~(,_,"> 39/ 52 sec ............................................~~(,_,"> 39/ 51 sec .............................................~~(,_,"> 40/ 51 sec ..............................................~~(,_,"> 41/ 52 sec ...............................................~~(,_,"> 41/ 51 sec ...............................................~~(,_,"> 42/ 51 sec ................................................~~(,_,"> 43/ 52 sec .................................................~~(,_,"> 44/ 52 sec ..................................................~~(,_,"> 44/ 51 sec ..................................................~~(,_,"> 45/ 52 sec ...................................................~~(,_,"> 46/ 52 sec ....................................................~~(,_,"> 46/ 51 sec .....................................................~~(,_,"> 47/ 52 sec ......................................................~~(,_,"> 48/ 52 sec ......................................................~~(,_,"> 48/ 51 sec .......................................................~~(,_,"> 49/ 52 sec ........................................................~~(,_,"> 50/ 52 sec .........................................................~~(,_,"> 50/ 51 sec .........................................................~~(,_,"> 51/ 52 sec ..........................................................~~(,_,"> 51/ 51 sec ...........................................................~~(,_,"> 52/ 51 sec ............................................................~~(,_,"> 52/ 52 sec ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 1/ 18 sec ...~~(,_,"> 1/ 16 sec ...~~(,_,"> 1/ 15 sec ...~~(,_,"> 1/ 14 sec ....~~(,_,"> 1/ 13 sec ....~~(,_,"> 1/ 12 sec ....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 10 sec .....~~(,_,"> 1/ 10 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 8 sec ......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 3.35 degrees; offsets= 2.38 pixels CurrentResolution= 27.125 Angstroms, which requires orientationSampling of at least 8.78049 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.160382 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000387445 Gb, available memory = 16 Gb. Expectation iteration 13 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 4/ 60 sec ...~~(,_,"> 0.08/1.03 min ....~~(,_,"> 0.10/1.08 min .....~~(,_,"> 0.12/1.10 min ......~~(,_,"> 0.13/1.12 min .......~~(,_,"> 0.13/1.02 min .......~~(,_,"> 0.15/1.03 min ........~~(,_,"> 0.17/1.05 min .........~~(,_,"> 0.18/1.08 min ..........~~(,_,"> 0.20/1.08 min ..........~~(,_,"> 0.20/1.02 min ...........~~(,_,"> 0.22/1.03 min ............~~(,_,"> 0.23/1.05 min .............~~(,_,"> 0.25/1.07 min ..............~~(,_,"> 0.27/1.08 min ..............~~(,_,"> 0.28/1.08 min ...............~~(,_,"> 0.28/1.03 min ................~~(,_,"> 0.30/1.05 min .................~~(,_,"> 0.32/1.05 min .................~~(,_,"> 0.33/1.07 min ..................~~(,_,"> 0.35/1.08 min ...................~~(,_,"> 0.35/1.03 min ....................~~(,_,"> 0.37/1.05 min ....................~~(,_,"> 0.38/1.05 min .....................~~(,_,"> 0.38/1.02 min ......................~~(,_,"> 0.40/1.02 min .......................~~(,_,"> 0.42/1.03 min .......................~~(,_,"> 25/ 60 sec ........................~~(,_,"> 0.43/1.02 min .........................~~(,_,"> 0.45/1.02 min ..........................~~(,_,"> 27/ 59 sec ...........................~~(,_,"> 28/ 60 sec ...........................~~(,_,"> 29/ 60 sec ............................~~(,_,"> 0.50/1.02 min .............................~~(,_,"> 0.52/1.02 min ..............................~~(,_,"> 31/ 60 sec ..............................~~(,_,"> 32/ 60 sec ...............................~~(,_,"> 33/ 60 sec ................................~~(,_,"> 0.57/1.02 min .................................~~(,_,"> 0.58/1.02 min ..................................~~(,_,"> 35/ 60 sec ..................................~~(,_,"> 36/ 60 sec ...................................~~(,_,"> 0.62/1.02 min ....................................~~(,_,"> 0.63/1.02 min .....................................~~(,_,"> 0.65/1.02 min .....................................~~(,_,"> 39/ 60 sec ......................................~~(,_,"> 40/ 60 sec .......................................~~(,_,"> 0.68/1.02 min ........................................~~(,_,"> 41/ 60 sec ........................................~~(,_,"> 42/ 60 sec .........................................~~(,_,"> 43/ 60 sec ..........................................~~(,_,"> 0.73/1.02 min ...........................................~~(,_,"> 0.75/1.02 min ............................................~~(,_,"> 45/ 60 sec ............................................~~(,_,"> 46/ 60 sec .............................................~~(,_,"> 47/ 60 sec ..............................................~~(,_,"> 0.80/1.02 min ...............................................~~(,_,"> 0.82/1.02 min ...............................................~~(,_,"> 49/ 60 sec ................................................~~(,_,"> 50/ 60 sec .................................................~~(,_,"> 0.85/1.02 min ..................................................~~(,_,"> 0.87/1.02 min ..................................................~~(,_,"> 52/ 60 sec ...................................................~~(,_,"> 53/ 60 sec ....................................................~~(,_,"> 54/ 60 sec .....................................................~~(,_,"> 0.92/1.02 min ......................................................~~(,_,"> 55/ 60 sec ......................................................~~(,_,"> 56/ 60 sec .......................................................~~(,_,"> 57/ 60 sec ........................................................~~(,_,"> 57/ 59 sec .........................................................~~(,_,"> 58/ 60 sec .........................................................~~(,_,"> 59/ 60 sec ..........................................................~~(,_,"> 60/ 60 sec ...........................................................~~(,_,"> 60/ 59 sec ............................................................~~(,_,"> 1.02/1.02 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 3.05 degrees; offsets= 2.31 pixels CurrentResolution= 24.1111 Angstroms, which requires orientationSampling of at least 7.82609 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.165398 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000447258 Gb, available memory = 16 Gb. Expectation iteration 14 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.10/1.25 min ....~~(,_,"> 0.12/1.25 min .....~~(,_,"> 0.13/1.27 min ......~~(,_,"> 0.15/1.27 min .......~~(,_,"> 0.15/1.13 min .......~~(,_,"> 0.17/1.15 min ........~~(,_,"> 0.18/1.17 min .........~~(,_,"> 0.20/1.17 min ..........~~(,_,"> 0.22/1.18 min ..........~~(,_,"> 0.22/1.10 min ...........~~(,_,"> 0.23/1.12 min ............~~(,_,"> 0.25/1.13 min .............~~(,_,"> 0.27/1.13 min ..............~~(,_,"> 0.28/1.15 min ..............~~(,_,"> 0.30/1.15 min ...............~~(,_,"> 0.32/1.15 min ................~~(,_,"> 0.33/1.17 min .................~~(,_,"> 0.35/1.17 min .................~~(,_,"> 0.35/1.12 min ..................~~(,_,"> 0.37/1.13 min ...................~~(,_,"> 0.38/1.13 min ....................~~(,_,"> 0.38/1.08 min ....................~~(,_,"> 0.40/1.10 min .....................~~(,_,"> 0.42/1.10 min ......................~~(,_,"> 0.43/1.12 min .......................~~(,_,"> 0.43/1.08 min .......................~~(,_,"> 0.45/1.08 min ........................~~(,_,"> 0.47/1.08 min .........................~~(,_,"> 0.48/1.10 min ..........................~~(,_,"> 0.48/1.07 min ...........................~~(,_,"> 0.50/1.07 min ...........................~~(,_,"> 0.52/1.08 min ............................~~(,_,"> 0.53/1.08 min .............................~~(,_,"> 0.55/1.08 min ..............................~~(,_,"> 0.57/1.08 min ..............................~~(,_,"> 0.57/1.07 min ...............................~~(,_,"> 0.58/1.07 min ................................~~(,_,"> 0.60/1.08 min .................................~~(,_,"> 0.62/1.08 min ..................................~~(,_,"> 0.63/1.08 min ..................................~~(,_,"> 0.65/1.08 min ...................................~~(,_,"> 0.67/1.10 min ....................................~~(,_,"> 0.67/1.07 min .....................................~~(,_,"> 0.68/1.08 min .....................................~~(,_,"> 0.70/1.08 min ......................................~~(,_,"> 0.72/1.08 min .......................................~~(,_,"> 0.73/1.08 min ........................................~~(,_,"> 0.73/1.07 min ........................................~~(,_,"> 0.75/1.07 min .........................................~~(,_,"> 0.77/1.08 min ..........................................~~(,_,"> 0.78/1.08 min ...........................................~~(,_,"> 0.78/1.07 min ............................................~~(,_,"> 0.80/1.07 min ............................................~~(,_,"> 0.82/1.07 min .............................................~~(,_,"> 0.83/1.07 min ..............................................~~(,_,"> 0.83/1.05 min ...............................................~~(,_,"> 0.85/1.05 min ...............................................~~(,_,"> 0.87/1.07 min ................................................~~(,_,"> 0.88/1.07 min .................................................~~(,_,"> 0.90/1.07 min ..................................................~~(,_,"> 0.90/1.05 min ..................................................~~(,_,"> 0.92/1.05 min ...................................................~~(,_,"> 0.93/1.07 min ....................................................~~(,_,"> 0.95/1.07 min .....................................................~~(,_,"> 0.95/1.05 min ......................................................~~(,_,"> 0.97/1.05 min ......................................................~~(,_,"> 0.98/1.05 min .......................................................~~(,_,"> 1.00/1.05 min ........................................................~~(,_,"> 1.02/1.07 min .........................................................~~(,_,"> 1.03/1.07 min .........................................................~~(,_,"> 1.05/1.07 min ..........................................................~~(,_,"> 1.05/1.05 min ...........................................................~~(,_,"> 1.07/1.05 min ............................................................~~(,_,"> 1.07/1.07 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 8 sec ......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.95 degrees; offsets= 2.26 pixels CurrentResolution= 22.8421 Angstroms, which requires orientationSampling of at least 7.34694 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.165398 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000447258 Gb, available memory = 16 Gb. Expectation iteration 15 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 3/ 55 sec ...~~(,_,"> 4/ 60 sec ...~~(,_,"> 0.08/1.03 min ....~~(,_,"> 0.10/1.08 min .....~~(,_,"> 6/ 57 sec ......~~(,_,"> 7/ 59 sec .......~~(,_,"> 0.13/1.02 min .......~~(,_,"> 0.15/1.03 min ........~~(,_,"> 0.17/1.05 min .........~~(,_,"> 0.18/1.08 min ..........~~(,_,"> 11/ 60 sec ..........~~(,_,"> 0.20/1.02 min ...........~~(,_,"> 0.22/1.03 min ............~~(,_,"> 0.23/1.05 min .............~~(,_,"> 14/ 60 sec ..............~~(,_,"> 15/ 60 sec ..............~~(,_,"> 0.27/1.02 min ...............~~(,_,"> 0.28/1.03 min ................~~(,_,"> 0.30/1.05 min .................~~(,_,"> 0.32/1.05 min .................~~(,_,"> 0.32/1.02 min ..................~~(,_,"> 0.33/1.02 min ...................~~(,_,"> 0.35/1.03 min ....................~~(,_,"> 21/ 60 sec ....................~~(,_,"> 22/ 60 sec .....................~~(,_,"> 0.38/1.02 min ......................~~(,_,"> 0.40/1.02 min .......................~~(,_,"> 0.42/1.03 min .......................~~(,_,"> 25/ 60 sec ........................~~(,_,"> 0.43/1.02 min .........................~~(,_,"> 0.45/1.02 min ..........................~~(,_,"> 0.47/1.03 min ...........................~~(,_,"> 28/ 60 sec ...........................~~(,_,"> 29/ 60 sec ............................~~(,_,"> 0.50/1.02 min .............................~~(,_,"> 0.52/1.02 min ..............................~~(,_,"> 0.53/1.03 min ..............................~~(,_,"> 32/ 60 sec ...............................~~(,_,"> 33/ 60 sec ................................~~(,_,"> 0.57/1.02 min .................................~~(,_,"> 0.58/1.02 min ..................................~~(,_,"> 35/ 60 sec ..................................~~(,_,"> 36/ 60 sec ...................................~~(,_,"> 0.62/1.02 min ....................................~~(,_,"> 37/ 59 sec .....................................~~(,_,"> 38/ 60 sec .....................................~~(,_,"> 39/ 60 sec ......................................~~(,_,"> 40/ 60 sec .......................................~~(,_,"> 40/ 59 sec ........................................~~(,_,"> 41/ 60 sec ........................................~~(,_,"> 42/ 60 sec .........................................~~(,_,"> 42/ 59 sec ..........................................~~(,_,"> 43/ 59 sec ...........................................~~(,_,"> 44/ 60 sec ............................................~~(,_,"> 45/ 60 sec ............................................~~(,_,"> 45/ 59 sec .............................................~~(,_,"> 46/ 59 sec ..............................................~~(,_,"> 47/ 59 sec ...............................................~~(,_,"> 48/ 60 sec ...............................................~~(,_,"> 49/ 60 sec ................................................~~(,_,"> 50/ 60 sec .................................................~~(,_,"> 50/ 59 sec ..................................................~~(,_,"> 51/ 60 sec ..................................................~~(,_,"> 52/ 60 sec ...................................................~~(,_,"> 53/ 60 sec ....................................................~~(,_,"> 54/ 60 sec .....................................................~~(,_,"> 0.92/1.02 min ......................................................~~(,_,"> 0.93/1.02 min ......................................................~~(,_,"> 0.95/1.02 min .......................................................~~(,_,"> 57/ 60 sec ........................................................~~(,_,"> 58/ 60 sec .........................................................~~(,_,"> 0.98/1.02 min .........................................................~~(,_,"> 1.00/1.02 min ..........................................................~~(,_,"> 60/ 60 sec ...........................................................~~(,_,"> 61/ 60 sec ............................................................~~(,_,"> 1.02/1.02 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ...........................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 1/ 1 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.95 degrees; offsets= 2.21 pixels CurrentResolution= 20.6667 Angstroms, which requires orientationSampling of at least 6.66667 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.173616 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000545025 Gb, available memory = 16 Gb. Expectation iteration 16 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.12/1.47 min ....~~(,_,"> 0.13/1.43 min .....~~(,_,"> 0.15/1.42 min ......~~(,_,"> 0.17/1.40 min .......~~(,_,"> 0.18/1.40 min .......~~(,_,"> 0.20/1.38 min ........~~(,_,"> 0.22/1.38 min .........~~(,_,"> 0.23/1.37 min ..........~~(,_,"> 0.23/1.27 min ..........~~(,_,"> 0.25/1.27 min ...........~~(,_,"> 0.27/1.28 min ............~~(,_,"> 0.28/1.28 min .............~~(,_,"> 0.30/1.28 min ..............~~(,_,"> 0.32/1.28 min ..............~~(,_,"> 0.33/1.28 min ...............~~(,_,"> 0.35/1.28 min ................~~(,_,"> 0.38/1.33 min .................~~(,_,"> 0.38/1.28 min .................~~(,_,"> 0.40/1.28 min ..................~~(,_,"> 0.42/1.28 min ...................~~(,_,"> 0.43/1.28 min ....................~~(,_,"> 0.45/1.28 min ....................~~(,_,"> 0.47/1.28 min .....................~~(,_,"> 0.48/1.28 min ......................~~(,_,"> 0.50/1.28 min .......................~~(,_,"> 0.52/1.28 min .......................~~(,_,"> 0.53/1.28 min ........................~~(,_,"> 0.55/1.28 min .........................~~(,_,"> 0.57/1.28 min ..........................~~(,_,"> 0.58/1.28 min ...........................~~(,_,"> 0.60/1.28 min ...........................~~(,_,"> 0.62/1.28 min ............................~~(,_,"> 0.63/1.28 min .............................~~(,_,"> 0.63/1.25 min ..............................~~(,_,"> 0.65/1.25 min ..............................~~(,_,"> 0.67/1.25 min ...............................~~(,_,"> 0.68/1.25 min ................................~~(,_,"> 0.70/1.25 min .................................~~(,_,"> 0.72/1.25 min ..................................~~(,_,"> 0.72/1.23 min ..................................~~(,_,"> 0.73/1.23 min ...................................~~(,_,"> 0.75/1.23 min ....................................~~(,_,"> 0.77/1.23 min .....................................~~(,_,"> 0.77/1.20 min .....................................~~(,_,"> 0.78/1.22 min ......................................~~(,_,"> 0.80/1.22 min .......................................~~(,_,"> 0.82/1.22 min ........................................~~(,_,"> 0.83/1.22 min ........................................~~(,_,"> 0.85/1.22 min .........................................~~(,_,"> 0.87/1.22 min ..........................................~~(,_,"> 0.88/1.22 min ...........................................~~(,_,"> 0.88/1.20 min ............................................~~(,_,"> 0.90/1.20 min ............................................~~(,_,"> 0.92/1.20 min .............................................~~(,_,"> 0.93/1.20 min ..............................................~~(,_,"> 0.95/1.20 min ...............................................~~(,_,"> 0.95/1.18 min ...............................................~~(,_,"> 0.97/1.18 min ................................................~~(,_,"> 0.98/1.18 min .................................................~~(,_,"> 1.00/1.18 min ..................................................~~(,_,"> 1.00/1.17 min ..................................................~~(,_,"> 1.02/1.17 min ...................................................~~(,_,"> 1.03/1.17 min ....................................................~~(,_,"> 1.05/1.18 min .....................................................~~(,_,"> 1.07/1.18 min ......................................................~~(,_,"> 1.08/1.18 min ......................................................~~(,_,"> 1.10/1.18 min .......................................................~~(,_,"> 1.12/1.18 min ........................................................~~(,_,"> 1.13/1.18 min .........................................................~~(,_,"> 1.15/1.18 min .........................................................~~(,_,"> 1.17/1.18 min ..........................................................~~(,_,"> 1.17/1.17 min ...........................................................~~(,_,"> 1.18/1.17 min ............................................................~~(,_,"> 1.18/1.18 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec .............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ..............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ...............~~(,_,"> 0/ 0 sec ................~~(,_,"> 0/ 0 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ..................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ...................................~~(,_,"> 1/ 1 sec ....................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec .......................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec ........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec .........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 1/ 1 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.9 degrees; offsets= 2.14 pixels CurrentResolution= 19.7273 Angstroms, which requires orientationSampling of at least 6.42857 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.176541 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000579759 Gb, available memory = 16 Gb. Expectation iteration 17 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.10/1.25 min ....~~(,_,"> 0.10/1.08 min .....~~(,_,"> 0.12/1.10 min ......~~(,_,"> 0.13/1.12 min .......~~(,_,"> 0.15/1.13 min .......~~(,_,"> 0.15/1.03 min ........~~(,_,"> 0.17/1.05 min .........~~(,_,"> 0.18/1.08 min ..........~~(,_,"> 0.20/1.08 min ..........~~(,_,"> 0.22/1.10 min ...........~~(,_,"> 0.23/1.12 min ............~~(,_,"> 0.25/1.13 min .............~~(,_,"> 0.27/1.13 min ..............~~(,_,"> 0.28/1.15 min ..............~~(,_,"> 0.32/1.22 min ...............~~(,_,"> 0.33/1.22 min ................~~(,_,"> 0.35/1.22 min .................~~(,_,"> 0.37/1.22 min .................~~(,_,"> 0.38/1.23 min ..................~~(,_,"> 0.38/1.18 min ...................~~(,_,"> 0.40/1.18 min ....................~~(,_,"> 0.42/1.18 min ....................~~(,_,"> 0.43/1.18 min .....................~~(,_,"> 0.45/1.20 min ......................~~(,_,"> 0.45/1.15 min .......................~~(,_,"> 0.47/1.17 min .......................~~(,_,"> 0.48/1.17 min ........................~~(,_,"> 0.50/1.17 min .........................~~(,_,"> 0.52/1.17 min ..........................~~(,_,"> 0.53/1.17 min ...........................~~(,_,"> 0.55/1.18 min ...........................~~(,_,"> 0.57/1.18 min ............................~~(,_,"> 0.58/1.18 min .............................~~(,_,"> 0.60/1.18 min ..............................~~(,_,"> 0.62/1.18 min ..............................~~(,_,"> 0.63/1.18 min ...............................~~(,_,"> 0.65/1.20 min ................................~~(,_,"> 0.67/1.20 min .................................~~(,_,"> 0.68/1.20 min ..................................~~(,_,"> 0.70/1.20 min ..................................~~(,_,"> 0.72/1.20 min ...................................~~(,_,"> 0.72/1.18 min ....................................~~(,_,"> 0.73/1.18 min .....................................~~(,_,"> 0.75/1.18 min .....................................~~(,_,"> 0.75/1.15 min ......................................~~(,_,"> 0.77/1.17 min .......................................~~(,_,"> 0.78/1.17 min ........................................~~(,_,"> 0.80/1.17 min ........................................~~(,_,"> 0.83/1.18 min .........................................~~(,_,"> 0.85/1.20 min ..........................................~~(,_,"> 0.87/1.20 min ...........................................~~(,_,"> 0.88/1.20 min ............................................~~(,_,"> 0.90/1.20 min ............................................~~(,_,"> 0.92/1.20 min .............................................~~(,_,"> 0.93/1.20 min ..............................................~~(,_,"> 0.95/1.20 min ...............................................~~(,_,"> 0.97/1.20 min ...............................................~~(,_,"> 0.98/1.20 min ................................................~~(,_,"> 1.00/1.20 min .................................................~~(,_,"> 1.02/1.20 min ..................................................~~(,_,"> 1.03/1.22 min ..................................................~~(,_,"> 1.05/1.22 min ...................................................~~(,_,"> 1.07/1.22 min ....................................................~~(,_,"> 1.08/1.22 min .....................................................~~(,_,"> 1.10/1.22 min ......................................................~~(,_,"> 1.12/1.22 min ......................................................~~(,_,"> 1.13/1.22 min .......................................................~~(,_,"> 1.15/1.22 min ........................................................~~(,_,"> 1.17/1.22 min .........................................................~~(,_,"> 1.17/1.20 min .........................................................~~(,_,"> 1.18/1.20 min ..........................................................~~(,_,"> 1.20/1.20 min ...........................................................~~(,_,"> 1.22/1.20 min ............................................................~~(,_,"> 1.22/1.22 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 1/ 14 sec ....~~(,_,"> 1/ 13 sec ....~~(,_,"> 1/ 12 sec ....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 10 sec .....~~(,_,"> 1/ 10 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 8 sec ......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 2/ 8 sec .............~~(,_,"> 2/ 8 sec ..............~~(,_,"> 2/ 8 sec ..............~~(,_,"> 2/ 8 sec ..............~~(,_,"> 2/ 8 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec .................~~(,_,"> 2/ 6 sec .................~~(,_,"> 2/ 6 sec .................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 3/ 5 sec ...................................~~(,_,"> 3/ 5 sec ...................................~~(,_,"> 3/ 5 sec ....................................~~(,_,"> 3/ 4 sec .......................................~~(,_,"> 3/ 4 sec .......................................~~(,_,"> 3/ 4 sec .......................................~~(,_,"> 3/ 4 sec ........................................~~(,_,"> 3/ 4 sec ........................................~~(,_,"> 3/ 4 sec ........................................~~(,_,"> 3/ 4 sec .........................................~~(,_,"> 3/ 4 sec .........................................~~(,_,"> 3/ 4 sec .........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 4/ 4 sec ...........................................................~~(,_,"> 4/ 4 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.9 degrees; offsets= 2.09 pixels CurrentResolution= 18.8696 Angstroms, which requires orientationSampling of at least 6.10169 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.179558 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000615567 Gb, available memory = 16 Gb. Expectation iteration 18 of 25 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.10/1.25 min ....~~(,_,"> 0.12/1.25 min .....~~(,_,"> 0.13/1.27 min ......~~(,_,"> 0.15/1.27 min .......~~(,_,"> 0.17/1.27 min .......~~(,_,"> 0.18/1.27 min ........~~(,_,"> 0.20/1.27 min .........~~(,_,"> 0.22/1.27 min ..........~~(,_,"> 0.23/1.27 min ..........~~(,_,"> 0.25/1.27 min ...........~~(,_,"> 0.27/1.28 min ............~~(,_,"> 0.28/1.28 min .............~~(,_,"> 0.32/1.35 min ..............~~(,_,"> 0.33/1.35 min ..............~~(,_,"> 0.35/1.35 min ...............~~(,_,"> 0.37/1.33 min ................~~(,_,"> 0.38/1.33 min .................~~(,_,"> 0.40/1.33 min .................~~(,_,"> 0.42/1.33 min ..................~~(,_,"> 0.43/1.33 min ...................~~(,_,"> 0.45/1.33 min ....................~~(,_,"> 0.47/1.33 min ....................~~(,_,"> 0.48/1.33 min .....................~~(,_,"> 0.50/1.33 min ......................~~(,_,"> 0.52/1.33 min .......................~~(,_,"> 0.53/1.33 min .......................~~(,_,"> 0.55/1.32 min ........................~~(,_,"> 0.57/1.32 min .........................~~(,_,"> 0.58/1.32 min ..........................~~(,_,"> 0.60/1.32 min ...........................~~(,_,"> 0.60/1.28 min ...........................~~(,_,"> 0.62/1.28 min ............................~~(,_,"> 0.63/1.28 min .............................~~(,_,"> 0.65/1.28 min ..............................~~(,_,"> 0.67/1.28 min ..............................~~(,_,"> 0.67/1.25 min ...............................~~(,_,"> 0.68/1.25 min ................................~~(,_,"> 0.70/1.25 min .................................~~(,_,"> 0.72/1.25 min ..................................~~(,_,"> 0.73/1.25 min ..................................~~(,_,"> 0.75/1.25 min ...................................~~(,_,"> 0.77/1.27 min ....................................~~(,_,"> 0.78/1.27 min .....................................~~(,_,"> 0.80/1.27 min .....................................~~(,_,"> 0.82/1.27 min ......................................~~(,_,"> 0.83/1.27 min .......................................~~(,_,"> 0.85/1.27 min ........................................~~(,_,"> 0.87/1.27 min ........................................~~(,_,"> 0.88/1.27 min .........................................~~(,_,"> 0.90/1.27 min ..........................................~~(,_,"> 0.90/1.23 min ...........................................~~(,_,"> 0.92/1.25 min ............................................~~(,_,"> 0.93/1.25 min ............................................~~(,_,"> 0.95/1.25 min .............................................~~(,_,"> 0.98/1.27 min ..............................................~~(,_,"> 1.00/1.27 min ...............................................~~(,_,"> 1.02/1.27 min ...............................................~~(,_,"> 1.03/1.27 min ................................................~~(,_,"> 1.05/1.27 min .................................................~~(,_,"> 1.07/1.27 min ..................................................~~(,_,"> 1.08/1.27 min ..................................................~~(,_,"> 1.10/1.27 min ...................................................~~(,_,"> 1.12/1.27 min ....................................................~~(,_,"> 1.13/1.27 min .....................................................~~(,_,"> 1.15/1.27 min ......................................................~~(,_,"> 1.15/1.25 min ......................................................~~(,_,"> 1.17/1.25 min .......................................................~~(,_,"> 1.18/1.25 min ........................................................~~(,_,"> 1.20/1.25 min .........................................................~~(,_,"> 1.22/1.25 min .........................................................~~(,_,"> 1.23/1.25 min ..........................................................~~(,_,"> 1.25/1.25 min ...........................................................~~(,_,"> 1.27/1.25 min ............................................................~~(,_,"> 1.27/1.27 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec .........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ..........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ...........~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 0/ 0 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 1/ 2 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ..............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ...............................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec ................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 1/ 1 sec .................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec .....................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec ......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec .......................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec ........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 2/ 2 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.9 degrees; offsets= 2.09 pixels CurrentResolution= 18.0833 Angstroms, which requires orientationSampling of at least 5.90164 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.182667 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000652447 Gb, available memory = 16 Gb. Expectation iteration 19 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.10/1.25 min ....~~(,_,"> 0.12/1.25 min .....~~(,_,"> 0.13/1.27 min ......~~(,_,"> 0.15/1.27 min .......~~(,_,"> 0.17/1.27 min .......~~(,_,"> 0.18/1.27 min ........~~(,_,"> 0.20/1.27 min .........~~(,_,"> 0.22/1.27 min ..........~~(,_,"> 0.23/1.27 min ..........~~(,_,"> 0.25/1.27 min ...........~~(,_,"> 0.27/1.28 min ............~~(,_,"> 0.28/1.28 min .............~~(,_,"> 0.32/1.35 min ..............~~(,_,"> 0.33/1.35 min ..............~~(,_,"> 0.35/1.35 min ...............~~(,_,"> 0.37/1.33 min ................~~(,_,"> 0.38/1.33 min .................~~(,_,"> 0.40/1.33 min .................~~(,_,"> 0.43/1.38 min ..................~~(,_,"> 0.43/1.33 min ...................~~(,_,"> 0.47/1.38 min ....................~~(,_,"> 0.47/1.33 min ....................~~(,_,"> 0.50/1.37 min .....................~~(,_,"> 0.52/1.37 min ......................~~(,_,"> 0.52/1.33 min .......................~~(,_,"> 0.53/1.33 min .......................~~(,_,"> 0.55/1.32 min ........................~~(,_,"> 0.57/1.32 min .........................~~(,_,"> 0.58/1.32 min ..........................~~(,_,"> 0.58/1.28 min ...........................~~(,_,"> 0.60/1.28 min ...........................~~(,_,"> 0.62/1.28 min ............................~~(,_,"> 0.63/1.28 min .............................~~(,_,"> 0.65/1.28 min ..............................~~(,_,"> 0.67/1.28 min ..............................~~(,_,"> 0.70/1.32 min ...............................~~(,_,"> 0.72/1.32 min ................................~~(,_,"> 0.73/1.32 min .................................~~(,_,"> 0.75/1.32 min ..................................~~(,_,"> 0.77/1.32 min ..................................~~(,_,"> 0.78/1.32 min ...................................~~(,_,"> 0.80/1.32 min ....................................~~(,_,"> 0.82/1.32 min .....................................~~(,_,"> 0.83/1.32 min .....................................~~(,_,"> 0.85/1.32 min ......................................~~(,_,"> 0.87/1.32 min .......................................~~(,_,"> 0.88/1.32 min ........................................~~(,_,"> 0.90/1.32 min ........................................~~(,_,"> 0.92/1.32 min .........................................~~(,_,"> 0.93/1.32 min ..........................................~~(,_,"> 0.95/1.32 min ...........................................~~(,_,"> 0.97/1.32 min ............................................~~(,_,"> 0.98/1.32 min ............................................~~(,_,"> 1.02/1.33 min .............................................~~(,_,"> 1.02/1.32 min ..............................................~~(,_,"> 1.03/1.32 min ...............................................~~(,_,"> 1.05/1.32 min ...............................................~~(,_,"> 1.07/1.30 min ................................................~~(,_,"> 1.08/1.30 min .................................................~~(,_,"> 1.12/1.33 min ..................................................~~(,_,"> 1.12/1.30 min ..................................................~~(,_,"> 1.15/1.33 min ...................................................~~(,_,"> 1.17/1.33 min ....................................................~~(,_,"> 1.17/1.30 min .....................................................~~(,_,"> 1.18/1.30 min ......................................................~~(,_,"> 1.20/1.30 min ......................................................~~(,_,"> 1.22/1.30 min .......................................................~~(,_,"> 1.23/1.30 min ........................................................~~(,_,"> 1.25/1.30 min .........................................................~~(,_,"> 1.27/1.30 min .........................................................~~(,_,"> 1.28/1.30 min ..........................................................~~(,_,"> 1.30/1.30 min ...........................................................~~(,_,"> 1.33/1.32 min ............................................................~~(,_,"> 1.33/1.33 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec .......~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 0/ 0 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec ............................~~(,_,"> 1/ 2 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.9 degrees; offsets= 2.07 pixels CurrentResolution= 17.36 Angstroms, which requires orientationSampling of at least 5.625 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.185869 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000690401 Gb, available memory = 16 Gb. Expectation iteration 20 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.10/1.25 min ....~~(,_,"> 0.12/1.25 min .....~~(,_,"> 0.15/1.42 min ......~~(,_,"> 0.17/1.40 min .......~~(,_,"> 0.18/1.40 min .......~~(,_,"> 0.20/1.38 min ........~~(,_,"> 0.22/1.38 min .........~~(,_,"> 0.23/1.37 min ..........~~(,_,"> 0.25/1.37 min ..........~~(,_,"> 0.27/1.37 min ...........~~(,_,"> 0.28/1.35 min ............~~(,_,"> 0.30/1.35 min .............~~(,_,"> 0.32/1.35 min ..............~~(,_,"> 0.33/1.35 min ..............~~(,_,"> 0.35/1.35 min ...............~~(,_,"> 0.37/1.33 min ................~~(,_,"> 0.38/1.33 min .................~~(,_,"> 0.40/1.33 min .................~~(,_,"> 0.43/1.38 min ..................~~(,_,"> 0.45/1.38 min ...................~~(,_,"> 0.47/1.38 min ....................~~(,_,"> 0.48/1.38 min ....................~~(,_,"> 0.48/1.33 min .....................~~(,_,"> 0.50/1.33 min ......................~~(,_,"> 0.52/1.33 min .......................~~(,_,"> 0.53/1.33 min .......................~~(,_,"> 0.55/1.32 min ........................~~(,_,"> 0.57/1.32 min .........................~~(,_,"> 0.58/1.32 min ..........................~~(,_,"> 0.60/1.32 min ...........................~~(,_,"> 0.62/1.32 min ...........................~~(,_,"> 0.63/1.32 min ............................~~(,_,"> 0.65/1.32 min .............................~~(,_,"> 0.68/1.35 min ..............................~~(,_,"> 0.70/1.35 min ..............................~~(,_,"> 0.72/1.35 min ...............................~~(,_,"> 0.72/1.32 min ................................~~(,_,"> 0.73/1.32 min .................................~~(,_,"> 0.75/1.32 min ..................................~~(,_,"> 0.77/1.32 min ..................................~~(,_,"> 0.78/1.32 min ...................................~~(,_,"> 0.80/1.32 min ....................................~~(,_,"> 0.82/1.32 min .....................................~~(,_,"> 0.83/1.32 min .....................................~~(,_,"> 0.85/1.32 min ......................................~~(,_,"> 0.85/1.28 min .......................................~~(,_,"> 0.87/1.28 min ........................................~~(,_,"> 0.88/1.28 min ........................................~~(,_,"> 0.90/1.28 min .........................................~~(,_,"> 0.92/1.28 min ..........................................~~(,_,"> 0.95/1.32 min ...........................................~~(,_,"> 0.95/1.28 min ............................................~~(,_,"> 0.98/1.32 min ............................................~~(,_,"> 1.00/1.32 min .............................................~~(,_,"> 1.02/1.32 min ..............................................~~(,_,"> 1.03/1.32 min ...............................................~~(,_,"> 1.05/1.32 min ...............................................~~(,_,"> 1.07/1.30 min ................................................~~(,_,"> 1.08/1.30 min .................................................~~(,_,"> 1.10/1.30 min ..................................................~~(,_,"> 1.12/1.30 min ..................................................~~(,_,"> 1.13/1.30 min ...................................................~~(,_,"> 1.15/1.30 min ....................................................~~(,_,"> 1.18/1.33 min .....................................................~~(,_,"> 1.20/1.33 min ......................................................~~(,_,"> 1.22/1.32 min ......................................................~~(,_,"> 1.23/1.32 min .......................................................~~(,_,"> 1.25/1.32 min ........................................................~~(,_,"> 1.27/1.32 min .........................................................~~(,_,"> 1.28/1.32 min .........................................................~~(,_,"> 1.30/1.32 min ..........................................................~~(,_,"> 1.32/1.32 min ...........................................................~~(,_,"> 1.33/1.32 min ............................................................~~(,_,"> 1.33/1.33 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 1/ 2 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ..................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ...................................~~(,_,"> 2/ 3 sec ....................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.9 degrees; offsets= 2 pixels CurrentResolution= 17.36 Angstroms, which requires orientationSampling of at least 5.625 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.185869 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000690401 Gb, available memory = 16 Gb. Expectation iteration 21 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.07/1.62 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.10/1.50 min ...~~(,_,"> 0.12/1.47 min ....~~(,_,"> 0.13/1.43 min .....~~(,_,"> 0.15/1.42 min ......~~(,_,"> 0.15/1.27 min .......~~(,_,"> 0.17/1.27 min .......~~(,_,"> 0.18/1.27 min ........~~(,_,"> 0.20/1.27 min .........~~(,_,"> 0.22/1.27 min ..........~~(,_,"> 0.22/1.18 min ..........~~(,_,"> 0.23/1.18 min ...........~~(,_,"> 0.25/1.20 min ............~~(,_,"> 0.27/1.20 min .............~~(,_,"> 0.28/1.20 min ..............~~(,_,"> 0.30/1.22 min ..............~~(,_,"> 0.33/1.28 min ...............~~(,_,"> 0.35/1.28 min ................~~(,_,"> 0.37/1.28 min .................~~(,_,"> 0.38/1.28 min .................~~(,_,"> 0.40/1.28 min ..................~~(,_,"> 0.42/1.28 min ...................~~(,_,"> 0.43/1.28 min ....................~~(,_,"> 0.45/1.28 min ....................~~(,_,"> 0.47/1.28 min .....................~~(,_,"> 0.48/1.28 min ......................~~(,_,"> 0.50/1.28 min .......................~~(,_,"> 0.52/1.28 min .......................~~(,_,"> 0.53/1.28 min ........................~~(,_,"> 0.53/1.25 min .........................~~(,_,"> 0.57/1.28 min ..........................~~(,_,"> 0.58/1.28 min ...........................~~(,_,"> 0.60/1.28 min ...........................~~(,_,"> 0.62/1.28 min ............................~~(,_,"> 0.63/1.28 min .............................~~(,_,"> 0.65/1.28 min ..............................~~(,_,"> 0.67/1.28 min ..............................~~(,_,"> 0.68/1.28 min ...............................~~(,_,"> 0.70/1.28 min ................................~~(,_,"> 0.72/1.28 min .................................~~(,_,"> 0.73/1.28 min ..................................~~(,_,"> 0.75/1.28 min ..................................~~(,_,"> 0.77/1.28 min ...................................~~(,_,"> 0.78/1.28 min ....................................~~(,_,"> 0.80/1.28 min .....................................~~(,_,"> 0.82/1.28 min .....................................~~(,_,"> 0.83/1.28 min ......................................~~(,_,"> 0.85/1.28 min .......................................~~(,_,"> 0.87/1.28 min ........................................~~(,_,"> 0.88/1.28 min ........................................~~(,_,"> 0.90/1.28 min .........................................~~(,_,"> 0.92/1.28 min ..........................................~~(,_,"> 0.93/1.28 min ...........................................~~(,_,"> 0.95/1.28 min ............................................~~(,_,"> 0.97/1.28 min ............................................~~(,_,"> 0.98/1.28 min .............................................~~(,_,"> 1.00/1.28 min ..............................................~~(,_,"> 1.02/1.28 min ...............................................~~(,_,"> 1.03/1.28 min ...............................................~~(,_,"> 1.05/1.28 min ................................................~~(,_,"> 1.07/1.28 min .................................................~~(,_,"> 1.08/1.28 min ..................................................~~(,_,"> 1.10/1.28 min ..................................................~~(,_,"> 1.13/1.30 min ...................................................~~(,_,"> 1.15/1.30 min ....................................................~~(,_,"> 1.17/1.30 min .....................................................~~(,_,"> 1.18/1.30 min ......................................................~~(,_,"> 1.20/1.30 min ......................................................~~(,_,"> 1.22/1.30 min .......................................................~~(,_,"> 1.23/1.30 min ........................................................~~(,_,"> 1.25/1.30 min .........................................................~~(,_,"> 1.28/1.32 min .........................................................~~(,_,"> 1.30/1.32 min ..........................................................~~(,_,"> 1.32/1.32 min ...........................................................~~(,_,"> 1.33/1.32 min ............................................................~~(,_,"> 1.33/1.33 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec .....~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec ......~~(,_,"> 0/ 0 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec ........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec .........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 1/ 2 sec ..........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ..................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ...................................................~~(,_,"> 2/ 2 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.85 degrees; offsets= 1.97 pixels CurrentResolution= 16.6923 Angstroms, which requires orientationSampling of at least 5.45455 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.189163 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000729427 Gb, available memory = 16 Gb. Expectation iteration 22 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.10/1.25 min ....~~(,_,"> 0.12/1.25 min .....~~(,_,"> 0.13/1.27 min ......~~(,_,"> 0.15/1.27 min .......~~(,_,"> 0.17/1.27 min .......~~(,_,"> 0.20/1.38 min ........~~(,_,"> 0.20/1.27 min .........~~(,_,"> 0.22/1.27 min ..........~~(,_,"> 0.23/1.27 min ..........~~(,_,"> 0.25/1.27 min ...........~~(,_,"> 0.27/1.28 min ............~~(,_,"> 0.28/1.28 min .............~~(,_,"> 0.30/1.28 min ..............~~(,_,"> 0.32/1.28 min ..............~~(,_,"> 0.33/1.28 min ...............~~(,_,"> 0.35/1.28 min ................~~(,_,"> 0.38/1.33 min .................~~(,_,"> 0.40/1.33 min .................~~(,_,"> 0.42/1.33 min ..................~~(,_,"> 0.43/1.33 min ...................~~(,_,"> 0.45/1.33 min ....................~~(,_,"> 0.47/1.33 min ....................~~(,_,"> 0.48/1.33 min .....................~~(,_,"> 0.52/1.37 min ......................~~(,_,"> 0.53/1.37 min .......................~~(,_,"> 0.55/1.37 min .......................~~(,_,"> 0.57/1.37 min ........................~~(,_,"> 0.58/1.37 min .........................~~(,_,"> 0.60/1.37 min ..........................~~(,_,"> 0.63/1.40 min ...........................~~(,_,"> 0.65/1.40 min ...........................~~(,_,"> 0.67/1.38 min ............................~~(,_,"> 0.68/1.38 min .............................~~(,_,"> 0.72/1.42 min ..............................~~(,_,"> 0.73/1.42 min ..............................~~(,_,"> 0.75/1.42 min ...............................~~(,_,"> 0.77/1.42 min ................................~~(,_,"> 0.78/1.40 min .................................~~(,_,"> 0.80/1.40 min ..................................~~(,_,"> 0.82/1.40 min ..................................~~(,_,"> 0.83/1.40 min ...................................~~(,_,"> 0.85/1.40 min ....................................~~(,_,"> 0.87/1.40 min .....................................~~(,_,"> 0.88/1.40 min .....................................~~(,_,"> 0.90/1.38 min ......................................~~(,_,"> 0.92/1.38 min .......................................~~(,_,"> 0.93/1.38 min ........................................~~(,_,"> 0.95/1.38 min ........................................~~(,_,"> 0.97/1.38 min .........................................~~(,_,"> 0.98/1.38 min ..........................................~~(,_,"> 1.00/1.38 min ...........................................~~(,_,"> 1.02/1.38 min ............................................~~(,_,"> 1.03/1.38 min ............................................~~(,_,"> 1.05/1.38 min .............................................~~(,_,"> 1.07/1.37 min ..............................................~~(,_,"> 1.08/1.37 min ...............................................~~(,_,"> 1.10/1.37 min ...............................................~~(,_,"> 1.12/1.37 min ................................................~~(,_,"> 1.13/1.37 min .................................................~~(,_,"> 1.15/1.37 min ..................................................~~(,_,"> 1.17/1.37 min ..................................................~~(,_,"> 1.18/1.37 min ...................................................~~(,_,"> 1.18/1.35 min ....................................................~~(,_,"> 1.20/1.35 min .....................................................~~(,_,"> 1.23/1.37 min ......................................................~~(,_,"> 1.23/1.35 min ......................................................~~(,_,"> 1.27/1.37 min .......................................................~~(,_,"> 1.28/1.37 min ........................................................~~(,_,"> 1.32/1.38 min .........................................................~~(,_,"> 1.32/1.35 min .........................................................~~(,_,"> 1.35/1.37 min ..........................................................~~(,_,"> 1.37/1.37 min ...........................................................~~(,_,"> 1.37/1.35 min ............................................................~~(,_,"> 1.38/1.38 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ...~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec ....~~(,_,"> 0/ 0 sec .....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 10 sec .....~~(,_,"> 1/ 10 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 8 sec ......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec ......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 1/ 2 sec .......................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ...............................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec ................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 2/ 2 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.9 degrees; offsets= 1.97 pixels CurrentResolution= 16.6923 Angstroms, which requires orientationSampling of at least 5.45455 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.189163 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000729427 Gb, available memory = 16 Gb. Expectation iteration 23 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.10/1.50 min ...~~(,_,"> 0.12/1.47 min ....~~(,_,"> 0.13/1.43 min .....~~(,_,"> 0.15/1.42 min ......~~(,_,"> 0.17/1.40 min .......~~(,_,"> 0.17/1.27 min .......~~(,_,"> 0.18/1.27 min ........~~(,_,"> 0.20/1.27 min .........~~(,_,"> 0.23/1.37 min ..........~~(,_,"> 0.25/1.37 min ..........~~(,_,"> 0.27/1.37 min ...........~~(,_,"> 0.28/1.35 min ............~~(,_,"> 0.30/1.35 min .............~~(,_,"> 0.32/1.35 min ..............~~(,_,"> 0.33/1.35 min ..............~~(,_,"> 0.37/1.40 min ...............~~(,_,"> 0.38/1.40 min ................~~(,_,"> 0.40/1.40 min .................~~(,_,"> 0.42/1.40 min .................~~(,_,"> 0.43/1.38 min ..................~~(,_,"> 0.45/1.38 min ...................~~(,_,"> 0.47/1.38 min ....................~~(,_,"> 0.48/1.38 min ....................~~(,_,"> 0.50/1.37 min .....................~~(,_,"> 0.52/1.37 min ......................~~(,_,"> 0.55/1.42 min .......................~~(,_,"> 0.55/1.37 min .......................~~(,_,"> 0.58/1.40 min ........................~~(,_,"> 0.60/1.40 min .........................~~(,_,"> 0.62/1.40 min ..........................~~(,_,"> 0.63/1.40 min ...........................~~(,_,"> 0.65/1.40 min ...........................~~(,_,"> 0.67/1.38 min ............................~~(,_,"> 0.68/1.38 min .............................~~(,_,"> 0.72/1.42 min ..............................~~(,_,"> 0.73/1.42 min ..............................~~(,_,"> 0.75/1.42 min ...............................~~(,_,"> 0.77/1.42 min ................................~~(,_,"> 0.78/1.40 min .................................~~(,_,"> 0.82/1.43 min ..................................~~(,_,"> 0.83/1.43 min ..................................~~(,_,"> 0.87/1.45 min ...................................~~(,_,"> 0.88/1.45 min ....................................~~(,_,"> 0.90/1.45 min .....................................~~(,_,"> 0.92/1.45 min .....................................~~(,_,"> 0.93/1.45 min ......................................~~(,_,"> 0.95/1.43 min .......................................~~(,_,"> 0.97/1.43 min ........................................~~(,_,"> 0.98/1.43 min ........................................~~(,_,"> 1.02/1.45 min .........................................~~(,_,"> 1.03/1.45 min ..........................................~~(,_,"> 1.05/1.45 min ...........................................~~(,_,"> 1.07/1.45 min ............................................~~(,_,"> 1.08/1.45 min ............................................~~(,_,"> 1.10/1.43 min .............................................~~(,_,"> 1.13/1.47 min ..............................................~~(,_,"> 1.15/1.45 min ...............................................~~(,_,"> 1.17/1.45 min ...............................................~~(,_,"> 1.18/1.45 min ................................................~~(,_,"> 1.20/1.45 min .................................................~~(,_,"> 1.22/1.45 min ..................................................~~(,_,"> 1.23/1.45 min ..................................................~~(,_,"> 1.25/1.45 min ...................................................~~(,_,"> 1.27/1.43 min ....................................................~~(,_,"> 1.28/1.43 min .....................................................~~(,_,"> 1.32/1.45 min ......................................................~~(,_,"> 1.33/1.45 min ......................................................~~(,_,"> 1.35/1.45 min .......................................................~~(,_,"> 1.35/1.43 min ........................................................~~(,_,"> 1.37/1.43 min .........................................................~~(,_,"> 1.38/1.43 min .........................................................~~(,_,"> 1.40/1.42 min ..........................................................~~(,_,"> 1.42/1.42 min ...........................................................~~(,_,"> 1.43/1.42 min ............................................................~~(,_,"> 1.43/1.43 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ..~~(,_,"> 0/ 0 sec ...~~(,_,"> 1/ 18 sec ...~~(,_,"> 1/ 16 sec ...~~(,_,"> 1/ 15 sec ...~~(,_,"> 1/ 14 sec ....~~(,_,"> 1/ 13 sec ....~~(,_,"> 1/ 12 sec ....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 10 sec .....~~(,_,"> 1/ 10 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 8 sec ......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec ................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec .................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ..................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 3 sec ...................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec ....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 1/ 2 sec .....................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec ........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec .........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ..........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ...........................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec ............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec .............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 2/ 2 sec ..............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ..........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ...........................................................~~(,_,"> 3/ 3 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.83 degrees; offsets= 1.97 pixels CurrentResolution= 16.0741 Angstroms, which requires orientationSampling of at least 5.21739 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.19255 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000769526 Gb, available memory = 16 Gb. Expectation iteration 24 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.05/1.77 min .~~(,_,"> 0.07/1.62 min ..~~(,_,"> 0.08/1.53 min ...~~(,_,"> 0.10/1.50 min ...~~(,_,"> 0.12/1.47 min ....~~(,_,"> 0.13/1.43 min .....~~(,_,"> 0.15/1.42 min ......~~(,_,"> 0.17/1.40 min .......~~(,_,"> 0.18/1.40 min .......~~(,_,"> 0.20/1.38 min ........~~(,_,"> 0.22/1.38 min .........~~(,_,"> 0.23/1.37 min ..........~~(,_,"> 0.25/1.37 min ..........~~(,_,"> 0.27/1.37 min ...........~~(,_,"> 0.28/1.35 min ............~~(,_,"> 0.30/1.35 min .............~~(,_,"> 0.32/1.35 min ..............~~(,_,"> 0.33/1.35 min ..............~~(,_,"> 0.35/1.35 min ...............~~(,_,"> 0.38/1.40 min ................~~(,_,"> 0.40/1.40 min .................~~(,_,"> 0.42/1.40 min .................~~(,_,"> 0.43/1.38 min ..................~~(,_,"> 0.45/1.38 min ...................~~(,_,"> 0.48/1.43 min ....................~~(,_,"> 0.50/1.43 min ....................~~(,_,"> 0.52/1.42 min .....................~~(,_,"> 0.53/1.42 min ......................~~(,_,"> 0.53/1.37 min .......................~~(,_,"> 0.55/1.37 min .......................~~(,_,"> 0.58/1.40 min ........................~~(,_,"> 0.58/1.37 min .........................~~(,_,"> 0.62/1.40 min ..........................~~(,_,"> 0.63/1.40 min ...........................~~(,_,"> 0.65/1.40 min ...........................~~(,_,"> 0.67/1.38 min ............................~~(,_,"> 0.68/1.38 min .............................~~(,_,"> 0.70/1.38 min ..............................~~(,_,"> 0.73/1.42 min ..............................~~(,_,"> 0.75/1.42 min ...............................~~(,_,"> 0.77/1.42 min ................................~~(,_,"> 0.80/1.43 min .................................~~(,_,"> 0.82/1.43 min ..................................~~(,_,"> 0.83/1.43 min ..................................~~(,_,"> 0.85/1.43 min ...................................~~(,_,"> 0.87/1.42 min ....................................~~(,_,"> 0.88/1.42 min .....................................~~(,_,"> 0.90/1.42 min .....................................~~(,_,"> 0.92/1.42 min ......................................~~(,_,"> 0.93/1.42 min .......................................~~(,_,"> 0.95/1.42 min ........................................~~(,_,"> 0.97/1.42 min ........................................~~(,_,"> 0.98/1.40 min .........................................~~(,_,"> 1.02/1.43 min ..........................................~~(,_,"> 1.03/1.43 min ...........................................~~(,_,"> 1.05/1.42 min ............................................~~(,_,"> 1.08/1.45 min ............................................~~(,_,"> 1.12/1.47 min .............................................~~(,_,"> 1.13/1.47 min ..............................................~~(,_,"> 1.15/1.45 min ...............................................~~(,_,"> 1.17/1.45 min ...............................................~~(,_,"> 1.20/1.47 min ................................................~~(,_,"> 1.22/1.47 min .................................................~~(,_,"> 1.23/1.47 min ..................................................~~(,_,"> 1.25/1.47 min ..................................................~~(,_,"> 1.27/1.47 min ...................................................~~(,_,"> 1.28/1.47 min ....................................................~~(,_,"> 1.32/1.48 min .....................................................~~(,_,"> 1.33/1.47 min ......................................................~~(,_,"> 1.35/1.47 min ......................................................~~(,_,"> 1.37/1.47 min .......................................................~~(,_,"> 1.38/1.47 min ........................................................~~(,_,"> 1.40/1.47 min .........................................................~~(,_,"> 1.43/1.48 min .........................................................~~(,_,"> 1.45/1.48 min ..........................................................~~(,_,"> 1.47/1.47 min ...........................................................~~(,_,"> 1.48/1.47 min ............................................................~~(,_,"> 1.50/1.50 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,"> Estimating accuracies in the orientational assignment ... 000/??? sec ~~(,_,"> [oo] 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec ~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec .~~(,_,"> 0/ 0 sec ..~~(,_,"> 1/ 25 sec ..~~(,_,"> 1/ 22 sec ..~~(,_,"> 1/ 20 sec ...~~(,_,"> 1/ 18 sec ...~~(,_,"> 1/ 16 sec ...~~(,_,"> 1/ 15 sec ...~~(,_,"> 1/ 14 sec ....~~(,_,"> 1/ 13 sec ....~~(,_,"> 1/ 12 sec ....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 11 sec .....~~(,_,"> 1/ 10 sec .....~~(,_,"> 1/ 10 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 9 sec ......~~(,_,"> 1/ 8 sec ......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 8 sec .......~~(,_,"> 1/ 7 sec .......~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 7 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec ........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 6 sec .........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ..........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 5 sec ...........~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec ............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec .............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ..............~~(,_,"> 1/ 4 sec ...............~~(,_,"> 1/ 3 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ...............~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec ................~~(,_,"> 2/ 7 sec .................~~(,_,"> 2/ 6 sec .................~~(,_,"> 2/ 6 sec .................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ..................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 6 sec ...................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec ....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec .....................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec ......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 5 sec .......................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec ........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec .........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ..........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ...........................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec ............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec .............................~~(,_,"> 2/ 4 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ..............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ...............................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec ................................~~(,_,"> 2/ 3 sec .................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 2/ 3 sec .......................................~~(,_,"> 3/ 4 sec .......................................~~(,_,"> 3/ 4 sec ........................................~~(,_,"> 3/ 4 sec ........................................~~(,_,"> 3/ 4 sec ........................................~~(,_,"> 3/ 4 sec .........................................~~(,_,"> 3/ 4 sec .........................................~~(,_,"> 3/ 4 sec .........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ..........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ...........................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec ............................................~~(,_,"> 3/ 4 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec .............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ..............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ...............................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec ................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec .................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ..................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ...................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec ....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec .....................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec ......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec .......................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec ........................................................~~(,_,"> 3/ 3 sec .........................................................~~(,_,"> 4/ 4 sec .........................................................~~(,_,"> 4/ 4 sec .........................................................~~(,_,"> 4/ 4 sec .........................................................~~(,_,"> 4/ 4 sec ..........................................................~~(,_,"> 4/ 4 sec ..........................................................~~(,_,"> 4/ 4 sec ..........................................................~~(,_,"> 4/ 4 sec ...........................................................~~(,_,"> 4/ 4 sec ...........................................................~~(,_,"> 4/ 4 sec ...........................................................~~(,_,"> 4/ 4 sec ............................................................~~(,_,"> Auto-refine: Estimated accuracy angles= 2.83 degrees; offsets= 1.93 pixels CurrentResolution= 15.5 Angstroms, which requires orientationSampling of at least 5.07042 degrees for a particle of diameter 350 Angstroms Oversampling= 0 NrHiddenVariableSamplingPoints= 15120 OrientationalSampling= 10 NrOrientations= 36 TranslationalSampling= 2 NrTranslations= 21 ============================= Oversampling= 1 NrHiddenVariableSamplingPoints= 483840 OrientationalSampling= 5 NrOrientations= 288 TranslationalSampling= 1 NrTranslations= 84 ============================= Estimated memory for expectation step > 0.19603 Gb, available memory = 16 Gb. Estimated memory for maximization step > 0.000810698 Gb, available memory = 16 Gb. Expectation iteration 25 of 25 000/??? sec ~~(,_,"> [oo] 0.02/1.08 min ~~(,_,"> 0.03/1.17 min .~~(,_,"> 0.05/1.22 min ..~~(,_,"> 0.07/1.23 min ...~~(,_,"> 0.08/1.25 min ...~~(,_,"> 0.12/1.47 min ....~~(,_,"> 0.13/1.43 min .....~~(,_,"> 0.15/1.42 min ......~~(,_,"> 0.18/1.55 min .......~~(,_,"> 0.20/1.52 min .......~~(,_,"> 0.22/1.50 min ........~~(,_,"> 0.25/1.58 min .........~~(,_,"> 0.27/1.57 min ..........~~(,_,"> 0.28/1.55 min ..........~~(,_,"> 0.30/1.53 min ...........~~(,_,"> 0.33/1.60 min ............~~(,_,"> 0.35/1.58 min .............~~(,_,"> 0.37/1.57 min ..............~~(,_,"> 0.40/1.62 min ..............~~(,_,"> 0.42/1.60 min ...............~~(,_,"> 0.45/1.65 min ................~~(,_,"> 0.47/1.63 min .................~~(,_,"> 0.48/1.62 min .................~~(,_,"> 0.50/1.60 min ..................~~(,_,"> 0.52/1.58 min ...................~~(,_,"> 0.53/1.58 min ....................~~(,_,"> 0.57/1.62 min ....................~~(,_,"> 0.58/1.60 min .....................~~(,_,"> 0.60/1.60 min ......................~~(,_,"> 0.62/1.58 min .......................~~(,_,"> 0.65/1.62 min .......................~~(,_,"> 0.65/1.57 min ........................~~(,_,"> 0.68/1.60 min .........................~~(,_,"> 0.70/1.58 min ..........................~~(,_,"> 0.72/1.58 min ...........................~~(,_,"> 0.73/1.57 min ...........................~~(,_,"> 0.75/1.57 min ............................~~(,_,"> 0.77/1.55 min .............................~~(,_,"> 0.78/1.55 min ..............................~~(,_,"> 0.80/1.55 min ..............................~~(,_,"> 0.82/1.53 min ...............................~~(,_,"> 0.83/1.53 min ................................~~(,_,"> 0.85/1.53 min .................................~~(,_,"> 0.88/1.55 min ..................................~~(,_,"> 0.90/1.55 min ..................................~~(,_,"> 0.92/1.53 min ...................................~~(,_,"> 0.93/1.53 min ....................................~~(,_,"> 0.95/1.53 min .....................................~~(,_,"> 0.97/1.52 min .....................................~~(,_,"> 0.98/1.52 min ......................................~~(,_,"> 1.00/1.52 min .......................................~~(,_,"> 1.02/1.52 min ........................................~~(,_,"> 1.03/1.50 min ........................................~~(,_,"> 1.05/1.50 min .........................................~~(,_,"> 1.07/1.50 min ..........................................~~(,_,"> 1.08/1.50 min ...........................................~~(,_,"> 1.10/1.50 min ............................................~~(,_,"> 1.12/1.48 min ............................................~~(,_,"> 1.15/1.50 min .............................................~~(,_,"> 1.17/1.50 min ..............................................~~(,_,"> 1.18/1.50 min ...............................................~~(,_,"> 1.20/1.50 min ...............................................~~(,_,"> 1.22/1.50 min ................................................~~(,_,"> 1.23/1.48 min .................................................~~(,_,"> 1.25/1.48 min ..................................................~~(,_,"> 1.27/1.48 min ..................................................~~(,_,"> 1.28/1.48 min ...................................................~~(,_,"> 1.32/1.50 min ....................................................~~(,_,"> 1.33/1.50 min .....................................................~~(,_,"> 1.35/1.50 min ......................................................~~(,_,"> 1.37/1.48 min ......................................................~~(,_,"> 1.38/1.48 min .......................................................~~(,_,"> 1.40/1.48 min ........................................................~~(,_,"> 1.43/1.50 min .........................................................~~(,_,"> 1.45/1.50 min .........................................................~~(,_,"> 1.47/1.50 min ..........................................................~~(,_,"> 1.48/1.48 min ...........................................................~~(,_,"> 1.50/1.48 min ............................................................~~(,_,"> 1.52/1.52 min ............................................................~~(,_,"> Maximization ... 000/??? sec ~~(,_,"> [oo] 1/ 1 sec ............................................................~~(,_,">