bfbin2arm: Bayes Factor Design for Two-Arm Binomial Trials

Design and analysis of one- and two-stage binomial clinical phase II trials using Bayes factors. Implements Bayes factors for point-null and directional hypotheses, predictive densities under different hypotheses, and power and sample size calibration. Both one-arm trials with only a single treatment arm and two-arm trials with treatment and control arm are implemented for the one- and two-stage designs.

Version:	0.1.3
Depends:	R (≥ 4.0.0)
Imports:	stats, VGAM, dplyr, parallel, utils, ggplot2, patchwork, rlang
Suggests:	knitr, rmarkdown, kableExtra, testthat (≥ 3.0.0)
Published:	2026-06-01
DOI:	10.32614/CRAN.package.bfbin2arm
Author:	Riko Kelter [aut, cre]
Maintainer:	Riko Kelter <rkelter at uni-koeln.de>
License:	GPL-3
URL:	https://arxiv.org/abs/2511.23144, https://arxiv.org/abs/2603.01715, https://arxiv.org/abs/2502.02914
NeedsCompilation:	no
CRAN checks:	bfbin2arm results

Documentation:

Reference manual:

bfbin2arm.html , bfbin2arm.pdf

Vignettes:

Bayes-factor-based designs in bfbin2arm (source) Calibration of Bayesian one-stage designs for single-arm phase II trials with binary endpoints (source, R code) Optimal two-stage single-arm Bayes factor designs for phase II trials (source, R code) Optimal frequentist calibration for single-arm two-stage Bayes factor designs with binary endpoints (source, R code) Optimal full calibration for single-arm two-stage Bayes factor designs with binary endpoints (source, R code) Optimal hybrid calibration for single-arm two-stage Bayes factor designs with binary endpoints (source, R code) Optimal Bayesian calibration of two-arm two-stage Bayes factor designs with binary endpoints (source, R code) Bayesian calibration of two-arm one-stage Bayes factor designs with binary endpoints (source, R code)

Downloads:

Package source:	bfbin2arm_0.1.3.tar.gz
Windows binaries:	r-devel: bfbin2arm_0.1.2.zip, r-release: bfbin2arm_0.1.2.zip, r-oldrel: bfbin2arm_0.1.2.zip
macOS binaries:	r-release (arm64): bfbin2arm_0.1.3.tgz, r-oldrel (arm64): bfbin2arm_0.1.3.tgz, r-release (x86_64): bfbin2arm_0.1.2.tgz, r-oldrel (x86_64): bfbin2arm_0.1.3.tgz
Old sources:	bfbin2arm archive

Linking:

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