edema {nparLD} | R Documentation |
Measurements of skin temperatures in (degree Celcius/10) of both operated and non-operated hands from a group of patients who had a surgery on a hand.
data(edema)
Longitudinal data of 58 patients from both a treatment and a control group with skin temperatues taken on 4 occasions on each hand, which result in 8 occasions per patient.
Surgical procedures on the hand may lead to a postoperative edema and a reddening of the skin. This is related to an increase in the skin temperature. A randomized clinical study was conducted to investigate whether treatment with a substance (V) effects a faster reduction of the edema and reddening than a placebo (P). Each experimental group consists of 29 patients. Temperature measurements were taken on the same area of both the operated and non-operated hand on the day previous to the operation (day -1) as well as on the first, third and fifth day (days 1, 3, 5) subsequent to the surgery.
Brunner, E., Domhof, S., and Langer, F. (2002). Nonparametric Analysis of Longitudinal Data in Factorial Experiments,
Wiley, New York.
Brunner, E. and Langer, F. (1999). Nichtparametrische Analyse longitudinaler Daten, R. Oldenbourg Verlag, Munchen Wien.
## Analysis using F1-LD-F2 design ## data(edema) var<-c(edema[,"n01"],edema[,"n1"],edema[,"n3"],edema[,"n5"], edema[,"o01"],edema[,"o1"],edema[,"o3"],edema[,"o5"]) time1<-factor(c(rep("Healthy",232),rep("Operated",232))) time2<-c(rep(-1,58),rep(1,58),rep(3,58),rep(5,58), rep(-1,58),rep(1,58),rep(3,58),rep(5,58)) group<-rep(edema[,"Group"],8) subject<-rep(edema[,"Patient"],8) ex.f1f2<-f1.ld.f2(var, time1, time2, group, subject, time1.name = "Hand", time2.name = "Day", group.name = "Treatment", description=FALSE) ## Wald-type statistic ex.f1f2$Wald.test #$Wald.test # Statistic df p-value #Treatment 1.0725762 1 3.003643e-01 #Hand 25.8758257 1 3.641005e-07 #Day 36.8857947 3 4.864630e-08 #Treatment:Hand 0.3304448 1 5.653973e-01 #Day:Hand 47.3460508 3 2.933702e-10 #Treatment:Day 5.3048189 3 1.507900e-01 #Treatment:Hand:Day 1.6581652 3 6.462743e-01 ## ANOVA-type statistic ex.f1f2$ANOVA.test # Statistic df p-value #Treatment 1.0725762 1.000000 3.003668e-01 #Hand 25.8758257 1.000000 3.647569e-07 #Day 11.0630080 2.699667 9.682198e-07 #Treatment:Hand 0.3304448 1.000000 5.653986e-01 #Day:Hand 15.1854889 2.630202 6.208596e-09 #Treatment:Day 1.3342605 2.699667 2.625598e-01 #Treatment:Hand:Day 0.7170325 2.630202 5.242392e-01