breast {integrativeME} | R Documentation |
Clinical and a subset of gene expression data from the van de Vijver et al. (2002) study.
data(breast)
A list containing the following components:
type
cont
indep
MElogreg
or MEindep
model in the mixture of experts methodology.loc
MEloc
model in the mixture of experts methodology.loc.ind
The data set from van de Vijver et al. (2002) contains gene expression of tumors from 256 patients who were all treated by modified radical mastectomy or breast-conserving surgery. The authors also included some patients from the Van 't Veer et al. (2002) study and the censored patients were removed. The data were preprocessed and filtered to obtain 5,537 genes spotted on Agilent Hu25K microarrays. Eight prognostic factors were available in the clinical data and categorized as indicated by the authors.
For the location model, variables 'posnode' and 'chemotherapy' were merged into a single categorical variable (called the location variable).
See website from the refered article. The original data with 5,537 transcripts can be downloaded as an .RData file from http://www.math.univ-toulouse.fr/~lecao/package.html
van de Vijver, M.J., He, Y.D., van' t Veer, L.J., Dai, H., Hart, A.A.M., Voskuil, D.W., Schreiber, G.J., Peterse, J.L., Roberts, C., Marton, M.J. and others (2002). A gene-expression signature as a predictor of survival in breast cancer. New England Journal of Medicine, 347, 25, 1999–2009.
Hunt, L. and Jorgensen, M. (1999). Mixture model clustering using the MULTIMIX program. Australian & New Zealand Journal of Statistics, 41, 2, 154–171.