cns {integrativeME} | R Documentation |
Clinical and a subset of gene expression data from the Pomeroy et al. (2002) study.
data(breast)
A list containing the following components:
type
cont
indep
MElogreg
or MEindep
model in the mixture of experts methodology.loc
MEloc
model in the mixture of experts methodology.loc.ind
gene.name
cont
data set.
Medulloblastomas are embryonal tumors of the central nervous system (CNS). Pomeroy et al. (2002) investigated this malignant brain tumor of childhood as the response of therapy is difficult to predict. The biopsies of 60 patients were obtained before they received any treatment. The expression level of 7,128 genes were available, as well as five clinical variables
For the location model, variables 'Age' and 'Cx' were merged into a single categorical variable (called the location variable).
See website from the refered article. The original data with 7,128 transcripts can be downloaded as an .RData file from http://www.math.univ-toulouse.fr/~lecao/package.html
Pomeroy, S.L. and Tamayo, P. and Gaasenbeek, M. and Sturla, L.M. and Angelo, M. and McLaughlin, M.E. and Kim, J.Y.H. and Goumnerova, L.C. and Black, P.M. and Lau, C. and others (2002). Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature, 415, 6870, 436–442.
Hunt, L. and Jorgensen, M. (1999). Mixture model clustering using the MULTIMIX program. Australian & New Zealand Journal of Statistics, 41, 2, 154–171.